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Liver Acquisition with Volume AcquisitionInfoSheet: - Sequences -
Intro, Overview, 
Types of, 
etc.
 
(LAVA) The MRI technique LAVA is based on a 3 dimensional spoiled gradient echo pulse sequence. The optimized inversion pulse and a new fat suppression technique (called segmented special) provides enhanced image contrast and uniform fat suppression. Array spatial sensitivity encoding technique (ASSET) with partial data filling and shorter TR/TE enables to use short breath holds for dynamic liver imaging with multiple phases.
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Further Reading:
  Basics:
MR Field Notes
   by www.gehealthcare.com    
Liver ImagingForum -
there are related threadsMRI Resource Directory:
 - Liver Imaging -
 
Liver imaging can be performed with sonography, computed tomography (CT) and magnetic resonance imaging (MRI). Ultrasound is, caused by the easy access, still the first-line imaging method of choice; CT and MRI are applied whenever ultrasound imaging yields vague results. Indications are the characterization of metastases and primary liver tumors e.g., benign lesions such as focal nodular hyperplasia (FNH), adenoma, hemangioma and malignant lesions (cancer) such as hepatocellular carcinomas (HCC). The decision, which medical imaging modality is more suitable, MRI or CT, is dependent on the different factors. CT is less costly and more widely available; modern multislice scanners provide high spatial resolution and short scan times but has the disadvantage of radiation exposure.
With the introduction of high performance MR systems and advanced sequences the image quality of MRI for the liver has gained substantially. Fast spin echo or single shot techniques, often combined with fat suppression, are the most common T2 weighted sequences used in liver MRI procedures. Spoiled gradient echo sequences are used as ideal T1 weighted sequences for evaluating of the liver. The repetition time (TR) can be sufficiently long to acquire enough sections covering the entire liver in one pass, and to provide good signal to noise. The TE should be the shortest in phase echo time (TE), which provides strong T1 weighting, minimizes magnetic susceptibility effects, and permits acquisition within one breath hold to cover the whole liver. A flip angle of 80° provides good T1 weighting and less of power deposition and tissue saturation than a larger flip angle that would provide comparable T1 weighting.
Liver MRI is very dependent on the administration of contrast agents, especially when detection and characterization of focal lesions are the issues. Liver MRI combined with MRCP is useful to evaluate patients with hepatic and biliary disease.
Gadolinium chelates are typical non-specific extracellular agents diffusing rapidly to the extravascular space of tissues being cleared by glomerular filtration at the kidney. These characteristics are somewhat problematic when a large organ with a huge interstitial space like the liver is imaged. These agents provide a small temporal imaging window (seconds), after which they begin to diffuse to the interstitial space not only of healthy liver cells but also of lesions, reducing the contrast gradient necessary for easy lesion detection. Dynamic MRI with multiple phases after i.v. contrast media (Gd chelates), with arterial, portal and late phase images (similar to CT) provides additional information.
An additional advantage of MRI is the availability of liver-specific contrast agents (see also Hepatobiliary Contrast Agents). Gd-EOB-DTPA (gadoxetate disodium, Gadolinium ethoxybenzyl dimeglumine, EOVIST Injection, brand name in other countries is Primovist) is a gadolinium-based MRI contrast agent approved by the FDA for the detection and characterization of known or suspected focal liver lesions.
Gd-EOB-DTPA provides dynamic phases after intravenous injection, similarly to non-specific gadolinium chelates, and distributes into the hepatocytes and bile ducts during the hepatobiliary phase. It has up to 50% hepatobiliary excretion in the normal liver.
Since ferumoxides are not eliminated by the kidney, they possess long plasmatic half-lives, allowing circulation for several minutes in the vascular space. The uptake process is dependent on the total size of the particle being quicker for larger particles with a size of the range of 150 nm (called superparamagnetic iron oxide). The smaller ones, possessing a total particle size in the order of 30 nm, are called ultrasmall superparamagnetic iron oxide particles and they suffer a slower uptake by RES cells. Intracellular contrast agents used in liver MRI are primarily targeted to the normal liver parenchyma and not to pathological cells. Currently, iron oxide based MRI contrast agents are not marketed.
Beyond contrast enhanced MRI, the detection of fatty liver disease and iron overload has clinical significance due to the potential for evolution into cirrhosis and hepatocellular carcinoma. Imaging-based liver fat quantification (see also Dixon) provides noninvasively information about fat metabolism; chemical shift imaging or T2*-weighted imaging allow the quantification of hepatic iron concentration.

See also Abdominal Imaging, Primovistâ„¢, Liver Acquisition with Volume Acquisition (LAVA), T1W High Resolution Isotropic Volume Examination (THRIVE) and Bolus Injection.

For Ultrasound Imaging (USI) see Liver Sonography at Medical-Ultrasound-Imaging.com.
 
Images, Movies, Sliders:
 Anatomic Imaging of the Liver  Open this link in a new window
      

 MRI Liver T2 TSE  Open this link in a new window
    
 
Radiology-tip.comradAbdomen CT,  Biliary Contrast Agents
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Medical-Ultrasound-Imaging.comLiver Sonography,  Vascular Ultrasound Contrast Agents
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• View the NEWS results for 'Liver Imaging' (10).Open this link in a new window.

• View the DATABASE results for 'Liver Imaging' (13).Open this link in a new window

 
Further Reading:
  Basics:
Comparison of liver scintigraphy and the liver-spleen contrast in Gd-EOB-DTPA-enhanced MRI on liver function tests
Thursday, 18 November 2021   by www.nature.com    
Liver Imaging Today
Friday, 1 February 2013   by www.healthcare.siemens.it    
Elastography: A Useful Method in Depicting Liver Hardness
Thursday, 15 April 2010   by www.sciencedaily.com    
Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease
Friday, 1 June 2012   by www.ncbi.nlm.nih.gov    
  News & More:
Utility and impact of magnetic resonance elastography in the clinical course and management of chronic liver disease
Saturday, 20 January 2024   by www.nature.com    
Even early forms of liver disease affect heart health, Cedars-Sinai study finds
Thursday, 8 December 2022   by www.eurekalert.org    
For monitoring purposes, AI-aided MRI does what liver biopsy does with less risk, lower cost
Wednesday, 28 September 2022   by radiologybusiness.com    
Perspectum: High Liver Fat (Hepatic Steatosis) Linked to Increased Risk of Hospitalization in COVID-19 Patients With Obesity
Monday, 29 March 2021   by www.businesswire.com    
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
T2-Weighted Liver MRI Using the MultiVane Technique at 3T: Comparison with Conventional T2-Weighted MRI
Friday, 16 October 2015   by www.ncbi.nlm.nih.gov    
EORTC study aims to qualify ADC as predictive imaging biomarker in preoperative regimens
Monday, 4 January 2016   by www.eurekalert.org    
MRI effectively measures hemochromatosis iron burden
Saturday, 3 October 2015   by medicalxpress.com    
Total body iron balance: Liver MRI better than biopsy
Sunday, 15 March 2015   by www.eurekalert.org    
MRI Resources 
Brain MRI - Health - Non-English - Quality Advice - Stimulator pool - Education pool
 
Ln-PK-11195InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
Molecular imaging agents may be useful in bimodal imaging - fluorescence and MRI. Bimodal imaging of PBR expressing cells has been possible with Ln-PK-11195, a new imaging agent for the further study of mitochondrial function and its relationship to cancer cell proliferation. By preparing cocktails of both the Gd3+ and Eu3+ or Tb3+ complexes, it will be possible to obtain non-invasive anatomic-scale images by MRI and perform microscopic-scale imaging by fluorescence on the same cell or tissue.
New agents will be created, these include a long circulating bimetallic with enhanced relaxivity for MRI. In-vitro and in-vivo studies will show the safety and efficacy of these molecular imaging agents.
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• View the DATABASE results for 'Ln-PK-11195' (2).Open this link in a new window

Localization Techniques
 
Means of selecting a restricted region from which the signal is received. These can include the use of surface coils, with or without magnetic field gradients. Generally used to produce a spectrum from the desired region.
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Localized Magnetic Resonance
 
(LMR) A particular technique for obtaining NMR spectra, for example, of phosphorus, from a limited region by creating a sensitive volume with inhomogeneous applied gradient magnetic fields, which may be enhanced with the use of surface coils.
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