(DWI) Magnetic resonance imaging is sensitive to diffusion, because the diffusion of water molecules along a field gradient reduces the MR signal. In areas of lower diffusion the signal loss is less intense and the display from this areas is brighter. The use of a bipolar gradient pulse and suitable pulse sequences permits the acquisition of diffusion weighted images (images in which areas of rapid proton diffusion can be distinguished from areas with slow diffusion).
Based on echo planar imaging, multislice DWI is today a standard for imaging brain infarction. With enhanced gradients, the whole brain can be scanned within seconds. The degree of diffusion weighting correlates with the strength of the diffusion gradients, characterized by the b-value, which is a function of the gradient related parameters: strength, duration, and the period between diffusion gradients.
Certain illnesses show restrictions of diffusion, for example demyelinization and cytotoxic edema. Areas of cerebral infarction have decreased apparent diffusion, which results in increased signal intensity on diffusion weighted MRI scans. DWI has been demonstrated to be more sensitive for the early detection of stroke than standard pulse sequences and is closely related to temperature mapping.
DWIBS is a new diffusion weighted imaging technique for the whole body that produces PET-like images. The DWIBS sequence has been developed with the aim to detect lymph nodes and to differentiate normal and hyperplastic from metastatic lymph nodes. This may be possible caused by alterations in microcirculation and water diffusivity within cancer metastases in lymph nodes.

See also Diffusion Weighted Sequence, Perfusion Imaging, ADC Map, Apparent Diffusion Coefficient, and Diffusion Tensor Imaging.

(DIR or DIRT1) Double inversion recovery T1 measurement is a T1 weighted black blood MRA sequence in which the signal from blood is suppressed. The inversion time to suppress blood is described as the duration between the initial inversion pulse and time point that the longitudinal magnetization of blood reaches the zero point. The readout starts at the blood suppression inversion time (BSP TI) and blood in the imaging slice gives no signal. This inversion time is around 650 ms with a 60 beat per minute heart rate at 1.5 T.
The TI can be decreased by using a wider receive bandwidth, shorter echo train length and/or narrow trigger window. Wide bandwidth also decreases the blurring caused by long echo trains at the expense of signal to noise ratio. In case of in plane or slow flow the suppression of the signal from blood may be incomplete. With increased TE or change of the image plane the blood suppression can be improved.
Double inversion recovery is a breath hold technique with one image per acquisition used in cardiovascular imaging. The patient is instructed to hold the breath in expiration (if not possible also inspiration can be taken), so that the end diastolic volume in the cardiac chambers would be the same during entire scanning. DIR provides fine details of the boundary between the lumen and the wall of the cardiac chambers and main vascular and heart structures, pericardium, and mediastinal tissues.

(GE) An echo signal generated from a free induction decay by means of a bipolar switched magnetic gradient. The echo is produced by reversing the direction of a magnetic field gradient or by applying balanced pulses of magnetic field gradient before and after a refocusing RF pulse so as to cancel out the position dependent phase shifts that have accumulated due to the gradient.
In the latter case, the gradient echo is generally adjusted to be coincident with the RF spin echo. When the RF and gradient echoes are not coincident, the time of the gradient echo is denoted echo time (TE) and the difference in time between the echoes is denoted time difference (TD).
Gradient echo does not refocus the effects of main field inhomogeneity and therefore is generally used with a short echo time. Disadvantages of gradient echo imaging are compromised anatomic details and artifacts in regions with varying susceptibility e.g. between the air-containing sinuses and brain and especially between haemorrhages and normal tissue.

See also Susceptibility Artifact.

(Hb) Haemoglobin is the major endogenous oxygen-binding molecule, responsible for binding oxygen in the lung and transporting it to the tissues by means of the circulation. Haemoglobin is contained in very high concentration in the red blood cells.
Haemoglobin is an Fe chelate tightly binding one Fe ion in its II oxidation state where it carries the charge 2+ (ferrous iron). If an oxygen molecule is bound to Hb, Hb is called oxyhaemoglobin, if no oxygen molecule is bound it is called deoxyhaemoglobin. When haemoglobin is oxidized (i.e. in a haematoma), Fe2+ is transformed into Fe3+. The resulting haemoglobin is then called metoxyhaemoglobin (Hb Fe3+).
Deoxyhaemoglobin and metoxyhaemoglobin act as paramagnetic contrast agents in MR, while oxyhaemoglobin is diamagnetic. This partly explains the special appearance of an aging haematoma in MR imaging and is also the basic of the blood oxygenation level dependent contrast (BOLD) used in functional magnetic resonance imaging of the brain (fMRI).

The uniformity of the main magnetic field measured in ppm. In a defined volume it is the difference between maximum and minimum field strength and this multiplied by 1 million.
In MR, the homogeneity of the static magnetic field is an important criterion of the quality of the magnet. Homogeneity requirements for MR imaging are generally lower than the homogeneity requirements for NMR spectroscopy, but for most imaging techniques must be maintained over a large region.