(FRE) Flow related enhancement could be seen most for blood flow, but also for other liquids with some MR imaging techniques, as an increase in intensity due to the washout of saturated spins. FRE provides positive contrast ("bright blood") of vascular details in time of flight MRA as well as the physiologic characterization of blood flow.
If stationary spins within the scanned region experience only an incomplete T1 relaxation between the repeated radio frequency (RF) excitations, this results in fewer signal of the stationary tissue (compared to inflowing blood with completely relaxed spins).
The degree of the flow related enhancement is proportional to the blood flowvelocity and the used repetition time. The use of flow compensation (gradient moment nulling) improves the FRE especially in gradient echosequences.
The occurrence of a low signal in regions of flow. For a spin echo sequence, this is caused in part by a lack of refocusing of blood, which is excited by the 90° pulse but not by the 180° pulse. For a gradient echo sequence, this is caused by the dephasing of blood signal.