Means of selecting a restricted region from which the signal is received. These can include the use of surface coils, with or without magnetic field gradients. Generally used to produce a spectrum from the desired region.

(BOLD) In MRI the changes in blood oxygenation level are visible. Oxyhaemoglobin (the principal haemoglobin in arterial blood) has no substantial magnetic properties, but deoxyhaemoglobin (present in the draining veins after the oxygen has been unloaded in the tissues) is strongly paramagnetic. It can thus serve as an intrinsic paramagnetic contrast agent in appropriately performed brain MRI. The concentration and relaxation properties of deoxyhaemoglobin make it a susceptibility , e.g. T2 relaxation effective contrast agent with little effect on T1 relaxation.
During activation of the brain, the oxygen consumption of the local tissue increase by approximately 5% with that the oxygen tension will decrease. As a consequence, after a short period of time vasodilatation occurs, resulting in a local increase of blood volume and flow by 20 - 40%. The incommensurate change in local blood flow and oxygen extraction increases the local oxygen level.
By using T2 weighted gradient echo EPI sequences, which are highly susceptibility sensitive and fast enough to capture the three-dimensional nature of activated brain areas will show an increase in signal intensity as oxyhaemoglobin is diamagnetic and deoxyhaemoglobin is paramagnetic. Other MR pulse sequences, such as spoiled gradient echo pulse sequences are also used.
As the effects are subtle and of the order of 2% in 1.5 T MR imaging, sophisticated methodology, paradigms and data analysis techniques have to be used to consistently demonstrate the effect.
As the BOLD effect is due to the deoxygenated blood in the draining veins, the spatial localization of the region where there is increased blood flow resulting in decreased oxygen extraction is not as precisely defined as the morphological features in MRI. Rather there is a physiological blurring, and is estimated that the linear dimensions of the physiological spatial resolution of the BOLD phenomenon are around 3 mm at best.

(ISIS) Image selected in vivo spectroscopy is used as a localization sequence to provide complete gradient controlled three-dimensional localization with a reduced number of sequence cycles, e.g. for in vivo 31P spectroscopy. The ISIS method generates three 180° pulses prior to a 90° pulse, after which the free induction decay is recorded. Specific 180° pulses (slice-selective) are combined and the FID's added or subtracted to generate a spectrum.
An advantage of the ISIS method is that the magnetization (before the final 90° pulse) is predominantly along the z-axis and so T2 effects are relatively small. This explains the value of this technique for 31P data acquisition, because some phosphorus metabolites (e.g. ATP) have short T2 values.
A disadvantage is that eight acquisitions are required to accomplish the spatial localization, therefore the sequence cannot be used for localized shimming. Another problem, because any variation between these data collections (for example, due to movement) will degrade these applications, can be solved by incorporating outer volume suppression techniques such as OSIRIS (modified ISIS).

(PC) Phase contrast sequences are the basis of MRA techniques utilizing the change in the phase shifts of the flowing protons in the region of interest to create an image. Spins that are moving along the direction of a magnetic field gradient receive a phase shift proportional to their velocity.
In a phase contrast sequence two data sets with a different amount of flow sensitivity are acquired. This is usually accomplished by applying gradient pairs, which sequentially dephase and then rephase spins during the sequence. Both 2D and 3D acquisition techniques can be applied with phase contrast MRA.
The first data set is acquired with a flow compensated sequence, i. e. without flow sensitivity. The second data set is acquired with a flow sensitive sequence. The amount of flow sensitivity is controlled by the strength of the bipolar gradient pulse pair, which is incorporated into the sequence. Stationary tissue undergoes no effective phase change after the application of the two gradients. Caused by the different spatial localization of flowing blood to stationary tissue, it experiences a different size of the second bipolar gradient compared to the first. The result is a phase shift.
The raw data from the two data sets are subtracted. By comparing the phase of signals from each location in the two sequences the exact amount of motion induced phase change can be determined to have a map where pixel brightness is proportional to spatial velocity.
Phase contrast images represent the signal intensity of the velocity of spins at each point within the field of view. Regions that are stationary remain black while moving regions are represented as grey to white.
The phase shift is proportional to the spin's velocity, and this allows the quantitative assessment of flow velocities. The difference MRI signal has a maximum value for opposite directions. This velocity is typically referred to as venc, and depends on the pulse amplitude and distance between the gradient pulse pair. For velocities larger than venc the difference signal is decreased constantly until it gets zero. Therefore, in a phase contrast angiography it is important to correctly set the venc of the sequence to the maximum flow velocity which is expected during the measurement. High venc factors of the PC angiogram (more than 40 cm/sec) will selectively image the arteries (PCA - arteriography), whereas a venc factor of 20 cm/sec will perform the veins and sinuses (PCV or MRV - venography).

See also Flow Quantification, Contrast Enhanced MR Venography, Time of Flight Angiography, Time Resolved Imaging of Contrast Kinetics.

A coil consists of one or more loops of conductive wire, looped around the core of the coil. Coils are part of the hardware of MRI machines and are used to create a magnetic field or to detect a changing magnetic field by voltage induced in the wire. A coil is usually a physically small antenna.
The perfect coil produces a uniform magnetic field without significant radiation.
Different types of MRI coils are used in MR systems:
Gradient coils are used to produce controlled variations in the main magnetic field (B0) to provide spatial localization of the signals and to apply reversal pulses in some imaging techniques.
MR imaging radio frequency coils to receive and/or transmit the RF signal.
Shim coils provide auxiliary magnetic fields in order to compensate for inhomogeneities in the main magnetic field of the MRI machine.

See also Gradient Coil, Radio Frequency Coil, Hardware and Coil Loading.

See also the related POLL result: '3rd party coils are better than the original manufacturer coils'