(PC) Phase contrast sequences are the basis of MRA techniques utilizing the change in the phase shifts of the flowing protons in the region of interest to create an image. Spins that are moving along the direction of a magnetic field gradient receive a phase shift proportional to their velocity.
In a phase contrast sequence two data sets with a different amount of flow sensitivity are acquired. This is usually accomplished by applying gradient pairs, which sequentially dephase and then rephase spins during the sequence. Both 2D and 3D acquisition techniques can be applied with phase contrast MRA.
The first data set is acquired with a flow compensated sequence, i. e. without flow sensitivity. The second data set is acquired with a flow sensitive sequence. The amount of flow sensitivity is controlled by the strength of the bipolar gradient pulse pair, which is incorporated into the sequence. Stationary tissue undergoes no effective phase change after the application of the two gradients. Caused by the different spatial localization of flowing blood to stationary tissue, it experiences a different size of the second bipolar gradient compared to the first. The result is a phase shift.
The raw data from the two data sets are subtracted. By comparing the phase of signals from each location in the two sequences the exact amount of motion induced phase change can be determined to have a map where pixel brightness is proportional to spatial velocity.
Phase contrast images represent the signal intensity of the velocity of spins at each point within the field of view. Regions that are stationary remain black while moving regions are represented as grey to white.
The phase shift is proportional to the spin's velocity, and this allows the quantitative assessment of flow velocities. The difference MRI signal has a maximum value for opposite directions. This velocity is typically referred to as venc, and depends on the pulse amplitude and distance between the gradient pulse pair. For velocities larger than venc the difference signal is decreased constantly until it gets zero. Therefore, in a phase contrast angiography it is important to correctly set the venc of the sequence to the maximum flow velocity which is expected during the measurement. High venc factors of the PC angiogram (more than 40 cm/sec) will selectively image the arteries (PCA - arteriography), whereas a venc factor of 20 cm/sec will perform the veins and sinuses (PCV or MRV - venography).

See also Flow Quantification, Contrast Enhanced MR Venography, Time of Flight Angiography, Time Resolved Imaging of Contrast Kinetics.

The process of locating a MR signal by altering the phase of spins in one dimension with a pulsed magnetic field gradient along that dimension prior to the acquisition of the signal.
If a gradient field is briefly switched on and then off again at the beginning of the pulse sequence right after the radio frequency pulse, the magnetization of the external voxels will either precess faster or slower relative to those of the central voxels.
During readout of the signal, the phase of the xy-magnetization vector in different columns will thus systematically differ. When the x- or y- component of the signal is plotted as a function of the phase encoding step number n and thus of time n TR, it varies sinusoidally, fast at the left and right edges and slow at the center of the image. Voxels at the image edges along the phase encoding direction are thus characterized by a higher 'frequency' of rotation of their magnetization vectors than those towards the center.
As each signal component has experienced a different phase encoding gradient pulse, its exact spatial reconstruction can be specifically and precisely located by the Fourier transformation analysis. Spatial resolution is directly related to the number of phase encoding levels (gradients) used. The phase encoding direction can be chosen, e.g. whenever oblique MR images are acquired or when exchanging frequency and phase encoding directions to control wrap around artifacts.

(Gφ) The phase encoding gradient is a magnetic field gradient that allows the encoding of the spatial signal location along a second dimension by different spin phases. The phase encoding gradient is applied after slice selection and excitation (before the frequency encoding gradient), orthogonally to the other two gradients. The spatial resolution is directly related to the number of phase encoding steps (gradients).

Means of compensating for the non-ideal response of a system such as the magnetic field gradient system by modifying the input function.

Spectrum of NMR signal whose frequency components are broadened by a magnetic field gradient. In the simplest case (negligible line width, no relaxation effects, and no effects of prior gradients), it corresponds to a one-dimensional projection of the spin density along the direction of the gradient; in this form it is used in projection reconstruction imaging.