The Dixon technique is a
MRI method used for
fat suppression and/or fat quantification. The difference in magnetic resonance frequencies between fat and water-bound protons allows the separation of water and fat images based on the
chemical shift effect.
This imaging technique is named after Dixon, who published in 1984 the basic idea to use
phase differences to calculate water and fat components in
postprocessing. Dixon's method relies on acquiring an image when fat and water are 'in phase', and another in 'opposed phase' (
out of phase). These images are then added together to get water-only images, and subtracted to get fat-only images. Therefore, this sequence type can deliver up to 4 contrasts in one
measurement:
in phase, opposed
phase, water and fat images. An additional benefit of Dixon imaging is that source images and fat images are also available to the diagnosing physician.
The original two point Dixon sequence (number of points means the number of images acquired at different TE) had limited possibilities to optimize the
echo time,
spatial resolution,
slice thickness, and
scan time; but Dixon based
fat suppression can be very effective in areas of high
magnetic susceptibility, where other techniques fail. This insensitivity to magnetic
field inhomogeneity and the possibility of direct image-based water and fat quantification have currently generated high research interests and improvements to the basic method (three point Dixon).
The combination of Dixon with
gradient echo sequences allows for example
liver imaging with 4 image types in one breath hold. With Dixon
TSE/FSE an excellent
fat suppression with high
resolution can be achieved, particularly useful in
imaging of the extremities.
For low
bandwidth imaging,
chemical shift correction of fat images can be made before recombination with water images to produce images free of
chemical shift displacement artifacts. The need to acquire more echoes lengthens the minimum
scan time, but the lack of fat
saturation pulses extends the maximum slice coverage resulting in comparable
scan time.