A signal to noise improvement method that is accomplished by taking the average of several FID's made under similar conditions to suppress the effects of random variations or random artifacts.

A signal to noise improvement method that is accomplished by taking the average of several FID`s made under similar conditions to suppress the effects of random variations or random artifacts. It is a common method to increase the SNR by averaging several measurements of the signal.
The number of averages is also referred to as the number of excitations (NEX) or the number of acquisitions (NSA). Doubling the number of acquisitions will increase the SNR by √2. The approximate amount of improvement in signal to noise (SNR) ratio is calculated as the square root of the number of excitations.
By using multiple averages, respiratory motion can be reduced in the same way that multiple averages increase the signal to noise ratio. NEX/NSA will increase SNR but will not affect contrast unless the tissues are being lost in noise (low CNR). Scan time scales directly with NEX/NSA and SNR as the square root of NEX/NSA.
The use of phase array coils allows the number of signal averages to be decreased with their superior SNR and resolution, thereby decreasing scan time.

(ADC) A diffusion coefficient to differentiate T2 shine through effects or artifacts from real ischemic lesions. In the human brain, water diffusion is a three-dimensional process that is not truly random because the diffusional motion of water is impeded by natural barriers. These barriers are cell membranes, myelin sheaths, white matter fiber tracts, and protein molecules.
The apparent water diffusion coefficients can be calculated by acquiring two or more images with a different gradient duration and amplitude (b-values). The contrast in the ADC map depends on the spatially distributed diffusion coefficient of the acquired tissues and does not contain T1 and T2* values.
The increased sensitivity of diffusion-weighted MRI in detecting acute ischemia is thought to be the result of the water shift intracellularly restricting motion of water protons (cytotoxic edema), whereas the conventional T2 weighted images show signal alteration mostly as a result of vasogenic edema.
The reduced ADC value also could be the result of decreased temperature in the nonperfused tissues, loss of brain pulsations leading to a decrease in apparent proton motion, increased tissue osmolality associated with ischemia, or a combination of these factors. The lower ADC measurements seen with early ischemia, have not been fully established, however, a lower apparent ADC is a sensitive indicator of early ischemic brain at a stage when ischemic tissue remains potentially salvageable.

See also Diffusion Weighted Imaging and Diffusion Tensor Tractography.

(FLASH) A fast sequence producing signals called gradient echo with low flip angles. FLASH sequences are modifications, which incorporate or remove the effects of transverse coherence respectively.
FLASH uses a semi-random spoiler gradient after each echo to spoil the steady state (to destroy any remaining transverse magnetization) by causing a spatially dependent phase shift. The transverse steady state is spoiled but the longitudinal steady state depends on the T1 values and the flip angle. Extremely short TR times are possible, as a result the sequence provides a mechanism for gaining extremely high T1 contrast by imaging with TR times as brief as 20 to 30 msec while retaining reasonable signal levels. It is important to keep the TE as short as possible to suppress susceptibility artifacts.
The T1 contrast depends on the TR as well as on flip angle, with short TE.
Small flip angles and short TR results in proton density, and long TR in T2* weighting.
With large flip angles and short TR result T1 weighted images.

TR and flip angle adjustment:
TR 3000 ms, Flip Angle 90°
TR 1500 ms, Flip Angle 45°
TR 700 ms, Flip Angle 25°
TR 125 ms, Flip Angle 10°

The apparent ability to trade TR against flip angle for purposes of contrast and the variation in SNR as the scan time (TR) is reduced.

See also Gradient Echo Sequence.

(SNR or S/N) The signal to noise ratio is used in MRI to describe the relative contributions to a detected signal of the true signal and random superimposed signals ('background noise') - a criterion for image quality.
One common method to increase the SNR is to average several measurements of the signal, on the expectation that random contributions will tend to cancel out. The SNR can also be improved by sampling larger volumes (increasing the field of view and slice thickness with a corresponding loss of spatial resolution) or, within limits, by increasing the strength of the magnetic field used. Surface coils can also be used to improve local signal intensity. The SNR will depend, in part, on the electrical properties of the sample or patient being studied. The SNR increases in proportion to voxel volume (1/resolution), the square root of the number of acquisitions (NEX), and the square root of the number of scans (phase encodings). SNR decreases with the field of view squared (FOV2) and wider bandwidths. See also Signal Intensity and Spin Density.

Measuring SNR:
Record the mean value of a small ROI placed in the most homogeneous area of tissue with high signal intensity (e.g. white matter in thalamus). Calculate the standard deviation for the largest possible ROI placed outside the object in the image background (avoid ghosting/aliasing or eye movement artifact regions).
The SNR is then:
Mean Signal/Standard Deviation of Background Noise