(MTC) This
MRI method increases the
contrast by removing a portion of the total signal in tissue. An
off resonance radio frequency (RF) pulse saturates macromolecular protons to make them invisible (caused by their ultra-short
T2* relaxation times). The
MRI signal from semi-solid tissue like
brain parenchyma is reduced, and the signal from a more fluid component like blood is retained.
E.g.,
saturation of broad spectral lines may produce decreases in intensity of lines not directly saturated, through exchange of
magnetization between the corresponding states; more closely coupled states will show a greater resulting intensity change.
Magnetization transfer techniques make demyelinated
brain or
spine lesions (as seen e.g. in multiple sclerosis) better visible on
T2 weighted images as well as on
gadolinium contrast enhanced
T1 weighted images.
Off
resonance makes use of a selection
gradient during an
off resonance MTC pulse. The
gradient has a negative
offset frequency on the arterial side of the imaging volume (caudally more off resonant and cranially less off resonant). The net effect of this type of pulse is that the arterial blood outside the imaging volume will retain more of its
longitudinal magnetization, with more vascular signal when it enters the imaging volume.
Off resonance MTC saturates the venous blood, leaving the arterial blood untouched.
On resonance has no effect on the free water pool but will saturate the bound water pool and is the difference in T2 between the pools. Special
binomial pulses are transmitted causing the
magnetization of the free protons to remain unchanged. The z-magnetization returns to its original value. The
spins of the
bound pool with a short T2 experience
decay, resulting in a destroyed
magnetization after the
on resonance pulse.
See also
Magnetization Transfer.