T2 weighted imaging relies upon local dephasing of spins following the application of the transverse energy pulse. The contrast of a T2 weighted image is predominantly dependent on T2 and the T2 dependence will be increased by using a long echo time.
Fat has a shorter T2 time than water and relaxes or decays more readily than water. Since the amount of transverse magnetization in fat is small, fat generates very little signal on a strong T2 weighted contrast image and appears intermediate to dark. The T2 weighting is stronger with a longer TE. Water has a very high T2 constant, therefore has very high T2 signal and thus appears bright on a T2 contrast image. Cerebral white matter (fat containing) is less intense than grey matter. Flowing blood (flow effects) and haematomas (haemoglobin, haemosiderin) have a variable signal intensity on MR images.
Images created with TR's and TE's to enhance T2 contrast are referred to as T2 weighted images. Both T1 and T2 weighted images are acquired for most medical MRI examinations.

(USPIO) The class of the ultrasmall superparamagnetic iron oxide includes several chemically and pharmacologically very distinct materials, which may or may not be interchangeable for a specific use. Some ultrasmall SPIO particles (median diameter less than 50nm) are used as MRI contrast agents (Sinerem®, Combidex®), e.g. to differentiate metastatic from inflammatory lymph nodes. USPIO shows also potential for providing important information about angiogenesis in cancer tumors and could possibly complement MRI helping physicians to identify dangerous arteriosclerosis plaques.
Because of the disadvantageous large T2*//T1 ratio, USPIO compounds are less suitable for arterial bolus contrast enhanced magnetic resonance angiography than gadolinium complexes. The tiny ultrasmall superparamagnetic iron oxides do not accumulate in the RES system as fast as larger particles, which results in a long plasma half-life. USPIO particles, with a small median diameter (less than 10 nm), will accumulate in lymph nodes after an intravenous injection by e.g. direct transcapillary passage through endothelial venules. Once within the nodal parenchyma, phagocytic cells of the mononuclear phagocyte system take up the particles.
As a second way, USPIOs are subsequently taken up from then interstitium by lymphatic vessels and transported to regional lymph nodes. A lymph node with normal phagocytic function takes up a considerable amount and shows a reduction of the signal intensity caused by T2 shortening effects and magnetic susceptibility. Caused by the small uptake of the USPIOs in metastatic lymph nodes, they appear with less signal reduction, and permit the differentiation of healthy lymph nodes from normal-sized, metastatic nodes.

See also Superparamagnetic Contrast Agents, Superparamagnetic Iron Oxide, Very Small Superparamagnetic Iron Oxide Particles, Blood Pool Agents, Intracellular Contrast Agents.

(UBO) Subcortical 'bright objects' are commonly displayed on high field MR of the brain. These subcortical high signal intensity foci have been verified to be caused by tangential cross-sectional images of gyri and sulci.

The temporal variation of the flip angle (from one RF pulse to the next) to enhance SNR, and/or equalize the signal intensity for each phase encoding step.

A voxel is a volume element (volumetric and pixel) representing a value in the three dimensional space, corresponding to a pixel for a given slice thickness. Voxels are frequently used in the visualization and analysis of medical data. The Magnetic Resonance Imaging MRI pixel intensity is proportional to the signal intensity of the appropriate voxel.

See also Volumetric Imaging.