In MR, saturation is a nonequilibrium state with no net magnetization. The same amount of nuclear spins is aligned against and with the magnetic field. Saturation methods like FatSat, SPIR etc., work with a frequency selective saturation pulse for a specific chemical shift applied before the actual sequence starts. This saturation pulse adjusts the magnetization from tissue components to zero. The hydrogen nuclei of fat and water resonate at different frequencies, which makes it possible to excite just the fat with repeatedly applying RF pulses at the Larmor frequency with interpulse times compared to T1. The resulting signal is then destroyed with a gradient pulse (Spoiler Gradient Pulse). Fat is the chemical compound to be saturated at a fat saturation sequence. When the actual sequence follows, (e.g., a spin echo sequence) the unwanted suppressed component will not resonate.

See also Saturation Recovery.

The range of diagnostics and imaging systems of Siemens Medical Systems covers ultrasound, nuclear medicine, angiography, magnetic resonance, computer tomography and patient monitoring. Siemens is one of the three leading MRI manufacturers, which together account for approximately 80 percent of the MRI machines installed worldwide. Siemens currently offers the Allegra 3T MRI, which is for head scanning only, but the company will also be launching the Trio MRI, a 3T whole body scanner.
Siemens has formed partnerships with more than ten research institutions and private practitioners to define a comprehensive MRI examination and compare MR to currently established cardiovascular modalities, thereby defining optimal diagnosis and treatment.

MRI Scanners:

0.2T to 1.0T:
1.5T:
3.0T to 7.0T:
Hybrid Scanners:
Mobile Solutions:

(USPIO) The class of the ultrasmall superparamagnetic iron oxide includes several chemically and pharmacologically very distinct materials, which may or may not be interchangeable for a specific use. Some ultrasmall SPIO particles (median diameter less than 50nm) are used as MRI contrast agents (Sinerem®, Combidex®), e.g. to differentiate metastatic from inflammatory lymph nodes. USPIO shows also potential for providing important information about angiogenesis in cancer tumors and could possibly complement MRI helping physicians to identify dangerous arteriosclerosis plaques.
Because of the disadvantageous large T2*//T1 ratio, USPIO compounds are less suitable for arterial bolus contrast enhanced magnetic resonance angiography than gadolinium complexes. The tiny ultrasmall superparamagnetic iron oxides do not accumulate in the RES system as fast as larger particles, which results in a long plasma half-life. USPIO particles, with a small median diameter (less than 10 nm), will accumulate in lymph nodes after an intravenous injection by e.g. direct transcapillary passage through endothelial venules. Once within the nodal parenchyma, phagocytic cells of the mononuclear phagocyte system take up the particles.
As a second way, USPIOs are subsequently taken up from then interstitium by lymphatic vessels and transported to regional lymph nodes. A lymph node with normal phagocytic function takes up a considerable amount and shows a reduction of the signal intensity caused by T2 shortening effects and magnetic susceptibility. Caused by the small uptake of the USPIOs in metastatic lymph nodes, they appear with less signal reduction, and permit the differentiation of healthy lymph nodes from normal-sized, metastatic nodes.

See also Superparamagnetic Contrast Agents, Superparamagnetic Iron Oxide, Very Small Superparamagnetic Iron Oxide Particles, Blood Pool Agents, Intracellular Contrast Agents.

Inert hyperpolarized gases are under development for imaging air spaces, including those in the lungs. Because they mostly contain air and water, lungs are difficult organs to image.
These ventilation agents (gases) have potential in lung imaging and are currently used in studies of the pulmonary ventilation:
Specific isotopes of inert gases can be hyperpolarized. Hyperpolarized is a state in which almost all of the atoms nuclei are spinning in the same direction. Once the nuclei in the isotope 3He have been hyperpolarized using a laser, they remain in this state for several days. The inert, hyperpolarized gas can then be used in a lung imaging study, where the high concentration of polarized nuclei provides a sharp contrast in MRI. The technique is already being developed with a view to commercialization by Magnetic Imaging Technologies in Durham, North Carolina. According to the company, existing MRI equipment can be used with a few minor modifications, along with a gas polarizer. The technique could provide early detection and monitoring of pulmonary disease.
Hyperpolarized 129Xe can also be used as a magnetic resonance tracer because of its MR-enhanced sensitivity combined with its high solubility. This isotope differs from 3He in that it can dissolve in the blood. Strong enhancement of the nuclear spin polarization of xenon in the gas phase can be achieved by optical pumping of rubidium and subsequent spin-exchange with the xenon nuclei. This technique can increase the magnetic resonance signal of xenon by five orders of magnitude, thus allowing NMR detection of xenon in very low concentration. MR spectroscopy and imaging of optically polarized xenon shows considerable potential for medical applications (see also back projection imaging).
Nycomed Amersham anticipated the market for inert gases in pulmonary imaging. The company obtained an exclusive license for the use of helium (He) and xenon (Xe) as MRI contrast agents. Currently, the US FDA has not yet approved the commercial distribution of inert gas imaging equipment, because the technique is still undergoing trials.