Creation of images of objects such as the body by use of the nuclear magnetic resonance phenomenon. The immediate practical application involves imaging the distribution of hydrogen nuclei (protons) in the body. The image brightness in a given region depends on the spin density and the relaxation times, with their relative importance determined by the particular imaging technique employed. Image brightness is also affected by motion such as blood flow.

See also Zeugmatography and Magnetic Resonance Imaging MRI.

(NOE) A change in the steady state magnetization of a particular nucleus due to irradiation of a neighboring nucleus with, which it is coupled by means of a spin spin coupling interaction. This interaction must be the primary relaxation mechanism of these nuclei. Such an effect can occur during decoupling and must be taken into account for accurate intensity determinations during such procedures.

Paramagnetic materials attract and repel like normal magnets when subject to a magnetic field. This alignment of the atomic dipoles with the magnetic field tends to strengthen it, and is described by a relative magnetic permeability greater than unity. Paramagnetism requires that the atoms individually have permanent dipole moments even without an applied field, which typically implies a partially filled electron shell. In pure Paramagnetism (without an external magnetic field), these atomic dipoles do not interact with one another and are randomly oriented in the absence of an external field, resulting in zero net moment.
Paramagnetic materials in magnetic fields will act like magnets but when the field is removed, thermal motion will quickly disrupt the magnetic alignment. In general, paramagnetic effects are small (magnetic susceptibility of the order of 10^-3 to 10^-5).
In MRI, gadolinium (Gd) one of these paramagnetic materials is used as a contrast agent. Through interactions between the electron spins of the paramagnetic gadolinium and the water nuclei nearby, the relaxation rates (T1 and T2) of the water protons are increased (T1 and T2 times are decreased), causing an increase in signal on T1 weighted images.

See also contrast agents, magnetism, ferromagnetism, superparamagnetism, and diamagnetism.

(PSSE) Partial saturation sequence in which the signal is detected as a spin echo. Even though a spin echo is used, there will not necessarily be a significant contribution of the T2 relaxation time to image contrast, unless the echo time, TE, is on the order of or longer than T2.

(PRESS) Point resolved spectroscopy is a multi echo single shot technique to obtain spectral data. PRESS is a 90°-180°-180° (slice selective pulses) sequence. The 90° radio frequency pulse rotates the spins in the yx-plane, followed by the first 180° pulse (spin rotation in the xz-plane) and the second 180° pulse (spin rotation in the xy-plane), which gives the signal.
With the long echo times used in PRESS, there is a better visualization of metabolites with longer relaxation times. Many of the metabolites depicted by stimulated echo technique are not seen on point resolved spectroscopy, but PRESS is less susceptible to motion, diffusion, and quantum effects and has a better SNR than stimulated echo acquisition mode (STEAM).