The brain tissue is provided with a tight endothelial layer on vessels that acts as a filter for substances that reach the brain through the blood stream. This filter is called the blood brain barrier.
The blood brain barrier is responsible for the absence of contrast agent enhancement in normal brain tissue after administration of the iodinated or paramagnetic contrast media used in brain MRI and computed tomography (CT) diagnostic. The absence of contrast uptake in normal tissue provides the basis for differentiation from pathological brain tissue, which is conversely characterized by a disruption of the blood brain barrier.
MR imaging techniques capable to provide maps of cerebral activity. All these techniques are based on indirect assessment of local cerebral haemodynamics that have been demonstrated to be closely related to cerebral activity.
Two kinds of techniques have been developed:
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based on the assessment of the decrease in the content of deoxyhaemoglobin in local activated tissue that can be revealed as an increase of signal on T2* and T2 weightedsequences in which deoxyhaemoglobin has low signal (see Blood Oxygenation Level Dependent Contrast)
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based on the time of flight or flow-related enhancement that is revealed either directly with T1 weighted images or through the use of modified angiographic bolus tracking techniques.