Pharmacyclics is a pharmaceutical company developing novel agents to improve current therapeutic approaches to cancer, cardiovascular diseases, and inflammation. The company's proprietary products are derived from its core technology in biometallic chemistry. These products under development are based upon small molecules, which bind metals in a unique way and are capable of capturing and focusing forms of energy used in a variety of medical applications. The company has one product in registration with the FDA, Gadolite® Oral Suspension, a contrast agent for imaging the gastrointestinal tract; two products in clinical development, Gd-Tex (Motexafin gadolinium), a radiation sensitizer, Lu-Tex, a photosensitizer; and several compounds in preclinical development.

MRI Contrast Agents:

USA-based, privately hold, headquartered in Palo Alto and Beijing is the company bridging the traditional medical practices of Asia with advances in modern pharmaceuticals.

MRI Contrast Agents:

In a periodic function (such as rotational or sinusoidal motion), the position relative to a particular part of the cycle. An angular relationship describing the degree of synchronism between two sinusoidal waveforms of the same frequency.

Different stages of testing drugs in humans, from first application in humans through limited and broad clinical tests, to postmarketing studies. Preclinical trials are the testing in animals.

The phase angle f is in turn affected by resonance offsets due to magnetic field inhomogeneity. If f varies throughout the image, the result will be inhomogeneous signal intensity (shading).