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Progressive Saturation
 
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ProHance®InfoSheet: - Contrast Agents - 
Intro, Overview, 
Characteristics, 
Types of, 
etc.MRI Resource Directory:
 - Contrast Agents -
 
ProHance® consists of a nonionic gadolinium complex (Gadoteridol) used as a paramagnetic MR contrast agent.
ProHance® provides contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. ProHance® can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies.

WARNING: NEPHROGENIC SYSTEMIC FIBROSIS Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate less than 30 mL/min/1.73m2), or acute renal insufficiency of any severity due to the hepato-renal syndrome or in the perioperative liver transplantation period.

See Gadoteridol.
Drug Information and Specification
NAME OF COMPOUND
Gadoteridol, Gd-HP-DO3A
CENTRAL MOIETY
Gd2+
CONTRAST EFFECT
T1, Predominantly positive enhancement
r1=3.7, r2=4.8, B0=1.0T
PHARMACOKINETIC
Intravascular, extracellular, renal excretion
630 mosm/kgH2O
CONCENTRATION
0.5 mol/L, 279.3mg/ml
DOSAGE
0.1 mmol Gd/kg
PREPARATION
Finished product
INDICATION
Neuro/whole body
DEVELOPMENT STAGE
For sale
DISTRIBUTOR
See below
PRESENTATION
Vials of 5, 10, 15 and 20 mL
Glass syringes of 5, 10, 15 and 17 mL
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE
NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!
Distribution Information
TERRITORY
TRADE NAME
DEVELOPMENT
STAGE
DISTRIBUTOR
USA
EU
ProHance®
for sale
Australia
ProHance®
for sale
Japan
ProHance®
for sale
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• View the DATABASE results for 'ProHance®' (6).Open this link in a new window

 
Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
Prohance Product Information
   by www.drugs.com    
  News & More:
RSNA Statement on Gadolinium-Based MR Contrast Agents
Thursday, 1 February 2018   by www.rsna.org    
Spurious Hypocalcemia After Omniscan- or OptiMARK-Enhanced Magnetic Resonance Imaging: An Algorithm for Minimizing a False-Positive Laboratory Value
October 2004   by www.findarticles.com    
FDA Drug Safety Communication: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings
Tuesday, 19 December 2017   by www.fda.gov    
EMA's final opinion confirms restrictions on use of linear gadolinium agents in body scans
Friday, 21 July 2017   by www.ema.europa.eu    
MRI Resources 
Calculation - Open Directory Project - Guidance - Spectroscopy pool - MR Myelography - Non-English
 
Projection Profile
 
Spectrum of NMR signal whose frequency components are broadened by a magnetic field gradient. In the simplest case (negligible line width, no relaxation effects, and no effects of prior gradients), it corresponds to a one-dimensional projection of the spin density along the direction of the gradient; in this form it is used in projection reconstruction imaging.
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Projection Reconstruction Imaging
 
MR imaging technique in which a set of projection profiles of the body is obtained by observing MR signals in the presence of a suitable corresponding set of magnetic field gradients. Images can then be reconstructed using techniques analogous to those used in conventional computed tomography (CT), such as filtered back projection. It can be used for volume imaging or, with plane selection techniques, for sequential plane imaging.
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• View the DATABASE results for 'Projection Reconstruction Imaging' (3).Open this link in a new window

Proportionality Constant
 
Two quantities (x, y) are called proportional if they vary in such a way that one of the quantities is a constant multiple of the other, or equivalently if they have a constant ratio (k = y/x). This constant ratio (k) is called the proportionality constant or constant of proportionality of the proportionality relation.
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