See Flow Related Enhancement.

In parallel MR imaging, a reduced data set in the phase encoding direction(s) of k-space is acquired to shorten acquisition time, combining the signal of several coil arrays. The spatial information related to the phased array coil elements is utilized for reducing the amount of conventional Fourier encoding.
First, low-resolution, fully Fourier-encoded reference images are required for sensitivity assessment. Parallel imaging reconstruction in the Cartesian case is efficiently performed by creating one aliased image for each array element using discrete Fourier transformation. The next step then is to create an full FOV image from the set of intermediate images. Parallel reconstruction techniques can be used to improve the image quality with increased signal to noise ratio, spatial resolution, reduced artifacts, and the temporal resolution in dynamic MRI scans.
Parallel imaging algorithms can be divided into 2 main groups:
Image reconstruction produced by each coil (reconstruction in the image domain, after Fourier transform): SENSE (Sensitivity Encoding), PILS (Partially Parallel Imaging with Localized Sensitivity), ASSET.
Reconstruction of the Fourier plane of images from the frequency signals of each coil (reconstruction in the frequency domain, before Fourier transform): GRAPPA.
Additional techniques include SMASH, SPEEDER™, IPAT (Integrated Parallel Acquisition Techniques - derived of GRAPPA a k-space based technique) and mSENSE (an image based enhanced version of SENSE).

(PARACEST) The alteration of the proton density or total water signal changes contrast and can be detected by the MRI scanner. Paramagnetic chemical exchange saturation transfer contrast agents are based upon the magnetization transfer mechanism.
Lanthanide ion complexes formed with tetra-amide based ligands display unusually slow water exchange kinetics and this feature may be used to alter image contrast by applying a selective presaturation pulse in an imaging sequence. This results in chemical exchange saturation transfer (CEST) from the lanthanide-bound water to bulk water thereby altering image contrast.
Chemical Exchange Saturation Transfer (CEST) agents are a class of contrast agents that could potentially revolutionize the MRI field because of their improved sensitivity and can have a great impact on functional magnetic resonance imaging.

Magnetic relaxation in tissues can be enhanced using contrast agents. The most commonly used for MRI are the paramagnetic contrast agents, which have their strongest effect on the T1, by increasing T1 signal intensity in tissues where they have accumulated.
MRI collects signal from the water protons, but the presence of these contrast agents enhances the relaxation of water protons in their vicinity. Paramagnetic contrast agents contain magnetic centers that create magnetic fields approximately one thousand times stronger than those corresponding to water protons. These magnetic centers interact with water protons in exactly the same way as the neighboring protons, but with much stronger magnetic fields, and therefore, have a much greater impact on relaxation rates, particularly on T1. In MRI, contrast agents are routinely injected intravenously to help identify areas of hypervascularity, as in malignant tumors.

See also Contrast Agents, Gadovist®, MultiHance®, Omniscan®, OptiMARK®.

See also the related poll result: 'The development of contrast agents in MRI is'

Substances exhibiting paramagnetic properties are used as contrast agents in MR imaging. They have a small but positive magnetic susceptibility (magnetizability - tends to align along the magnetic field). Typical paramagnetic substances usually possess an unpaired electron and include atoms or ions of transition elements, rare earth elements, some metals, and some molecules including molecular oxygen and free radicals.

See also Paramagnetism.