Molecular imaging agents may be useful in bimodal imaging - fluorescence and MRI. Bimodal imaging of PBR expressing cells has been possible with Ln-PK-11195, a new imaging agent for the further study of mitochondrial function and its relationship to cancer cell proliferation. By preparing cocktails of both the Gd3+ and Eu3+ or Tb3+ complexes, it will be possible to obtain non-invasive anatomic-scale images by MRI and perform microscopic-scale imaging by fluorescence on the same cell or tissue.
New agents will be created, these include a long circulating bimetallic with enhanced relaxivity for MRI. In-vitro and in-vivo studies will show the safety and efficacy of these molecular imaging agents.

Texas-based university research group. Current projects include: 'Multi-Modal Molecular Imaging Agents' or 'Micro-Fluidics and Nanosensing'. For example, the research group is evaluating Ln-PK-11195 as a bimodal imaging contrast agent for brain cancer detection by MRI and fluorescence.
Please see their Current Projects Abstracts for complete coverage.