The company is a member of the Bracco Group, a highly innovative healthcare group and world leader in global integrated solutions for the diagnostic medical imaging field. The Bracco Group is headquartered in Milan, Italy. Its North American operations consist of Bracco Diagnostics and Bracco Research USA, both located in Princeton, New Jersey. Bracco Diagnostics is one of the fastest growing developers and marketers of diagnostic pharmaceuticals in North America, with products for various imaging applications, including Isovue® (iopamidol - X-ray contrast agent), ProHance® (gadoteridol - MRI contrast agent), SonoVue® (ultrasound contrast agent) and nuclear medicine products.
Gadoteridol has been available in Europe and the USA for several years. Holder of the Marketing Authorization: Bracco International B.V. - Strawinskylaan 3051 - 1077 ZX Amsterdam The Netherlands. (Contact: Kirk Deeter, Phone: +NL-303-838-8708)

MRI Contrast Agents:

Breath hold imaging in MRI is a technique with one ore more stoppage of breathing during the sequence and require therefore a short scan time. Breath hold techniques are used with fast gradient echo sequences in thoracic or abdominal regions with much respiratory movement.
Breath hold cine MRI techniques are used in cardiovascular imaging and provide detailed views of the beating heart in different cardiac axes.
Breath hold imaging requires the full cooperation of the patient, caused by usual MRI scan times from 15 to 20 sec.. In some cases breath holding can be practiced outside the MRI scanner to improve patient cooperation with the examination. Shorter scan times e.g. by parallel imaging techniques, or the administration of oxygen can help the patient to hold the breath during the scan.
See also Abdominal Imaging.

The cardiac anatomy is complex, and cardiac structures have different appearances depending on the imaging plane. The most useful imaging planes are those parallel and perpendicular to the cardiac axes. The short axis (SA), vertical long cardiac axis (VLA - 2 chamber view - 2C) and horizontal long axis (HLA - 4 chamber view - 4C) are the standard views in cardiovascular imaging. The orientation of a heart is described relative to an imaginary line drawn from the base of the heart (valve plane) to the apex.
Obtaining cine images in these double-oblique planes requires the use of multiple localizing MRI sequences and knowledge of the cardiac anatomy. The long axis image plane is determined by the line that runs from the apex of the heart to a midpoint at the base of the heart, often taken to be midway between the mitral valve leaflets. The short axis is planned perpendicular to the long axis view.

Cardiovascular MR imaging includes the complete anatomical display of the heart with CINE imaging of all phases of the heartbeat. Ultrafast techniques make breath hold three-dimensional coverage of the heart in different cardiac axes feasible. Cardiac MRI provides reliable anatomical and functional assessment of the heart and evaluation of myocardial viability and coronary artery disease by a noninvasive diagnostic imaging technique.
Cardiovascular MRI offers potential advantages over radioisotopic techniques because it provides superior spatial resolution, does not use ionizing radiation, has no imaging orientations constraints and contrast resolution better than echocardiography. It also offers direct visualization and characterization of atherosclerotic plaques and diseased vessel walls and surrounding tissues in cardiovascular research.
MRI perfusion approaches measure the alteration of regional myocardial magnetic properties after the intravenous injection of contrast agents and assess the extent of injury after a myocardial infarction and the presence of myocardial viability with a technique based on late enhancement. Extracellular MRI contrast agents, like Gd-DTPA, accumulate only in irreversibly damaged myocardium after a time period of at least 10 minutes.
This type of patients may also have an implanted cardiac stent, bypass or a cardiac pacemaker and special caution should be observed on the MRI safety and the contraindications. While a number of coronary stents have been tested and reported to be MRI compatible, coronary stents must be assessed on an individual basis, with the medical team weighing the risks and benefits of the MRI procedure.

Cardiac MRI overview:

Cardiovascular MRI has become one of the most effective noninvasive imaging techniques for almost all groups of heart and vascular disease.

(Cr(III)-labeled RBC's) Chromium labeled red blood cells have paramagnetic properties and potential as an intravascular MRI contrast agent. The labeling with chromium decreases the relaxation times of packed red blood cells (RBCs). The use of RBCs in nuclear medicine suggests a low toxicity.

See also Contrast Agents, Intravascular Contrast Agents, Blood Pool Agents.