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Fast Low Angle ShotInfoSheet: - Sequences - 
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(FLASH) A fast sequence producing signals called gradient echo with low flip angles. FLASH sequences are modifications, which incorporate or remove the effects of transverse coherence respectively.
FLASH uses a semi-random spoiler gradient after each echo to spoil the steady state (to destroy any remaining transverse magnetization) by causing a spatially dependent phase shift. The transverse steady state is spoiled but the longitudinal steady state depends on the T1 values and the flip angle. Extremely short TR times are possible, as a result the sequence provides a mechanism for gaining extremely high T1 contrast by imaging with TR times as brief as 20 to 30 msec while retaining reasonable signal levels. It is important to keep the TE as short as possible to suppress susceptibility artifacts.
The T1 contrast depends on the TR as well as on flip angle, with short TE.
Small flip angles and short TR results in proton density, and long TR in T2* weighting.
With large flip angles and short TR result T1 weighted images.

TR and flip angle adjustment:

TR 3000 ms, Flip Angle 90°
TR 1500 ms, Flip Angle 45°
TR 700 ms, Flip Angle 25°
TR 125 ms, Flip Angle 10°

The apparent ability to trade TR against flip angle for purposes of contrast and the variation in SNR as the scan time (TR) is reduced.

See also Gradient Echo Sequence.
 
Images, Movies, Sliders:
 Fetus (Brain) and Dermoid in Mother  Open this link in a new window
      

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    • Abdominal Imaging
    • Ultrafast Gradient Echo Sequence
    • T2 Weighted Image
    • Gradient Echo Sequence
    • Spoiled Gradient Echo Sequence
 
Further Reading:
  News & More:
Motion Compensation in MR Imaging
   by ccn.ucla.edu    
Turbo-FLASH Based Arterial Spin Labeled Perfusion MRI at 7 T
Thursday, 20 June 2013   by www.plosone.org    
Usefulness of MR Imaging for Diseases of the Small Intestine: Comparison with CT
2000   by www.ncbi.nlm.nih.gov    
MRI Resources 
Knee MRI - General - Fluorescence - MR Myelography - Breast MRI - Jobs pool
 
Turbo Fast Low Angle ShotInfoSheet: - Sequences - 
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Overview, 
Types of, 
etc.MRI Resource Directory:
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(TurboFLASH) This FLASH-based sequence use an inversion pulse followed by a low flip angle and short TR gradient echo train. This gradient echo technique forms complete images in times short compared to T1. Images obtained in this way have very little intrinsic contrast, maintaining adequate signal requires that losses (and therefore contrast).

See also Ultrafast Gradient Echo Sequence and Fast Low Angle Shot.
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MRI Resources 
Manufacturers - Implant and Prosthesis pool - Chemistry - Artifacts - Cochlear Implant - Shielding
 
MRI History
 
Sir Joseph Larmor (1857-1942) developed the equation that the angular frequency of precession of the nuclear spins being proportional to the strength of the magnetic field. [Larmor relationship]
In the 1930's, Isidor Isaac Rabi (Columbia University) succeeded in detecting and measuring single states of rotation of atoms and molecules, and in determining the mechanical and magnetic moments of the nuclei.
Felix Bloch (Stanford University) and Edward Purcell (Harvard University) developed instruments, which could measure the magnetic resonance in bulk material such as liquids and solids. (Both honored with the Nobel Prize for Physics in 1952.) [The birth of the NMR spectroscopy]
In the early 70's, Raymond Damadian (State University of New York) demonstrated with his NMR device, that there are different T1 relaxation times between normal and abnormal tissues of the same type, as well as between different types of normal tissues.
In 1973, Paul Lauterbur (State University of New York) described a new imaging technique that he termed Zeugmatography. By utilizing gradients in the magnetic field, this technique was able to produce a two-dimensional image (back-projection). (Through analysis of the characteristics of the emitted radio waves, their origin could be determined.) Peter Mansfield further developed the utilization of gradients in the magnetic field and the mathematically analysis of these signals for a more useful imaging technique. (Paul C Lauterbur and Peter Mansfield were awarded with the 2003 Nobel Prize in Medicine.)
In 1975, Richard Ernst introduced 2D NMR using phase and frequency encoding, and the Fourier Transform. Instead of Paul Lauterbur's back-projection, he timely switched magnetic field gradients ('NMR Fourier Zeugmatography'). [This basic reconstruction method is the basis of current MRI techniques.]
1977/78: First images could be presented. A cross section through a finger by Peter Mansfield and Andrew A. Maudsley. Peter Mansfield also could present the first image through the abdomen.
In 1977, Raymond Damadian completed (after 7 years) the first MR scanner (Indomitable). In 1978, he founded the FONAR Corporation, which manufactured the first commercial MRI scanner in 1980. Fonar went public in 1981.
1981: Schering submitted a patent application for Gd-DTPA dimeglumine.
1982: The first 'magnetization-transfer' imaging by Robert N. Muller.
In 1983, Toshiba obtained approval from the Ministry of Health and Welfare in Japan for the first commercial MRI system.
In 1984, FONAR Corporation receives FDA approval for its first MRI scanner.
1986: Jürgen Hennig, A. Nauerth, and Hartmut Friedburg (University of Freiburg) introduced RARE (rapid acquisition with relaxation enhancement) imaging. Axel Haase, Jens Frahm, Dieter Matthaei, Wolfgang Haenicke, and Dietmar K. Merboldt (Max-Planck-Institute, Göttingen) developed the FLASH (fast low angle shot) sequence.
1988: Schering's MAGNEVIST gets its first approval by the FDA.
In 1991, fMRI was developed independently by the University of Minnesota's Center for Magnetic Resonance Research (CMRR) and Massachusetts General Hospital's (MGH) MR Center.
From 1992 to 1997 Fonar was paid for the infringement of it's patents from 'nearly every one of its competitors in the MRI industry including giant multi-nationals as Toshiba, Siemens, Shimadzu, Philips and GE'.
 
Images, Movies, Sliders:
 Cardiac Infarct Short Axis Cine Overview  Open this link in a new window
    

Courtesy of  Robert R. Edelman
 
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• View the NEWS results for 'MRI History' (1).Open this link in a new window.
 
Further Reading:
  Basics:
Magnetic Resonance Imaging, History & Introduction
2000   by www.cis.rit.edu    
A Short History of the Magnetic Resonance Imaging (MRI)
   by www.teslasociety.com    
Fonar Our History
   by www.fonar.com    
  News & More:
Scientists win Nobels for work on MRI
Tuesday, 10 June 2003   by usatoday30.usatoday.com    
2001 Lemelson-MIT Lifetime Achievement Award Winner
   by web.mit.edu    
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
Searchterm 'Fast Low Angle Shot' was also found in the following service: 
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Spoiled Gradient Echo SequenceInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - Sequences -
 
Spoiled gradient echo sequences use a spoiler gradient on the slice select axis during the end module to destroy any remaining transverse magnetization after the readout gradient, which is the case for short repetition times.
As a result, only z-magnetization remains during a subsequent excitation. This types of sequences use semi-random changes in the phase of radio frequency pulses to produce a spatially independent phase shift.
Companies use different acronyms to describe certain techniques.

Different terms for these gradient echo pulse sequences:
CE-FFE-T1 Contrast Enhanced Fast Field Echo with T1 Weighting,
GFE Gradient Field Echo,
FLASH Fast Low Angle Shot,
PS Partial Saturation,
RF spoiled FAST RF Spoiled Fourier Acquired Steady State Technique,
RSSARGE Radio Frequency Spoiled Steady State Acquisition Rewound Gradient Echo
S-GRE Spoiled Gradient Echo,
SHORT Short Repetition Techniques,
SPGR Spoiled Gradient Recalled (spoiled GRASS),
STAGE T1W T1 weighted Small Tip Angle Gradient Echo,
T1-FAST T1 weighted Fourier Acquired Steady State Technique,
T1-FFE T1 weighted Fast Field Echo.
In this context, 'contrast enhanced' refers to the pulse sequence, it does not mean enhancement with a contrast agent.
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Further Reading:
  News & More:
3-D VOLUMETRIC IMAGING FOR STEREOTACTIC LESIONAL AND DEEP BRAIN STIMULATION SURGERY
Cutting Edge Imaging of THE Spine
February 2007   by www.pubmedcentral.nih.gov    
MRI Resources 
Safety Training - Claustrophobia - Pediatric and Fetal MRI - Liver Imaging - Case Studies - Calculation
 
TurboFLASHInfoSheet: - Sequences - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:
 - Sequences -
 
An ultrafast gradient echo pulse sequence with data acquisition after an initial 180° (similar to IR) preparation pulse for contrast enhancement.
See Fast Low Angle Shot and Ultrafast Gradient Echo Sequence.
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• View the DATABASE results for 'TurboFLASH' (7).Open this link in a new window

 
Further Reading:
  Basics:
MRI techniques improve pulmonary embolism detection
Monday, 19 March 2012   by medicalxpress.com    
Turbo-FLASH Based Arterial Spin Labeled Perfusion MRI at 7 T
Thursday, 20 June 2013   by www.plosone.org    
MRI Resources 
Software - Knee MRI - Brain MRI - Colonography - Raman Spectroscopy - Blood Flow Imaging
 
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