(DIR or DIRT1) Double inversion recovery T1 measurement is a T1 weightedblack blood MRA sequence in which the signal from blood is suppressed. The inversion time to suppress blood is described as the duration between the initial inversion pulse and time point that the longitudinal magnetization of blood reaches the zero point. The readout starts at the blood suppressioninversion time (BSP TI) and blood in the imaging slice gives no signal. This inversion time is around 650 ms with a 60 beat per minute heart rate at 1.5 T.
The TI can be decreased by using a wider receive bandwidth, shorter echo train length and/or narrow trigger window. Wide bandwidth also decreases the blurring caused by long echo trains at the expense of signal to noise ratio. In case of in plane or slow flow the suppression of the signal from blood may be incomplete. With increased TE or change of the image plane the blood suppression can be improved.
Double inversion recovery is a breath hold technique with one image per acquisition used in cardiovascular imaging. The patient is instructed to hold the breath in expiration (if not possible also inspiration can be taken), so that the end diastolic volume in the cardiac chambers would be the same during entire scanning. DIR provides fine details of the boundary between the lumen and the wall of the cardiac chambers and main vascular and heart structures, pericardium, and mediastinal tissues.
A type of magnet that utilizes coils of wire, typically wound on an iron core, so that as current flows through the coil it becomes magnetized. The direction of the magnetic field is parallel to the long axis of the coil. Whole body electromagnets, used in medical imaging (also called resistive) are limited to their field strength, because the weight becomes prohibitively large at high field MRI. The magnetic field shuts down, if the current is switched of. Because this type of magnet generates heat, a good cooling system is essential. For a stronger magnetic field, the wires must be manufactured of superconducting materials to reduce the power needed to produce the field.
Ferrioxamines are potential iron oxide-based intravascular contrast agents. Ferrioxamine methanesulfonate, ferrioxamine-B, and hydroxyethyl-starch-ferrioxamine have been tested as MRIcontrast agents, partly in clinical trials. Ferrioxamine methanesulfonate was tested as a paramagnetic agent for the imaging of the kidney and the urogenital system. Hydroxyethyl-starch-ferrioxamine has the potential to provide information regarding myocardial vascular flow and ferrioxamine-B derivatives may be used as hepatobiliary contrast agents.