(TOF) The time of flight angiography is used for the imaging of vessels. Usually the sequence type is a gradient echosequences with short TR, acquired with slices perpendicular to the direction of blood flow.
The source of diverse flow effects is the difference between the unsaturated and presaturated spins and creates a bright vascular image without the invasive use of contrast media. Flowing blood moves unsaturated spins from outside the slice into the imaging plane. These completely relaxed spins have full equilibriummagnetization and produce (when entering the imaging plane) a much higher signal than stationary spins if a gradient echo sequence is generated. This flow related enhancement is also referred to as entry slice phenomenon, or inflow enhancement.
Performing a presaturationslab on one side parallel to the slice can selectively destroy the MR signal from the in-flowing blood from this side of the slice. This allows the technique to be flow direction sensitive and to separate arteriograms or venograms. When the local magnetization of moving blood is selectively altered in a region, e.g. by selective excitation, it carries the altered magnetization with it when it moves, thus tagging the selected region for times on the order of the relaxation times.
For maximum flow signal, a complete new part of blood has to enter the slice every repetition (TR) period, which makes time of flight angiography sensitive to flow-velocity. The choice of TR and slice thickness should be appropriate to the expected flow-velocities because even small changes in slice thickness influences the performance of the TOF sequence.
The use of sequential 2 dimensional Fourier transformation (2DFT) slices, 3DFT slabs, or multiple 3D slabs (chunks) are depending on the coverage required and the range of flow-velocities.
3D TOF MRA is routinely used for evaluating the Circle of Willis.
Sharp changes in intensity (incomplete digitization of the echo)
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A data truncation artifact may occur when the interface between high and low signal intensities is encountered in one imaging plane. The 2D-FT techniques transform the MR signal to spatial intensity image data with frequency and phase information encoding each axis in the plane of the scan. This artifact is found in both frequency and phase axes.
Artifactual ripples adjacent to edges in an image or sharp features in a spectrum, caused by omission of higher frequency terms in Fourier transformation, particularly with the use of zero filling to replace unsampled higher frequencies.
Complex shapes are specified by series of sine and cosine waves of various frequencies, phase and amplitude. Some shapes are more difficult to encode than others. The most difficult shapes to represent with Fourier series of terms are waveforms with instantaneous transitions, tissue discontinuities or edges. The low-frequency components of the series describe the overall shape of the step function. Higher frequency components are needed to describe the corners if the step function more accurately.
If not enough samples are taken, these areas cannot be accurately represented.
The truncation of the infinite data series results in a ringing artifact because of the inability to accurately approximate this tissue discontinuity with a shorter truncated data set. Therefore, the ringing that occurs at all tissue boundaries on MR is called truncation artifact.
Substitution of zeroes for unmeasured data points in order to increase the matrix size of the new data prior to Fourier transformation of MR data. This can be equivalent to performing an interpolation (ZIP - zero fill interpolation processing) in the transformed data, resulting in pixels smaller than the actual resolution of the image.
• View the DATABASE results for 'Zero Filling' (4).
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