The term in phase refers to an image in which the signals from two spectral components (such as fat and water) add constructively in a voxel.
T1 weighted in phase images are acquired by a gradient echo-based technique with a short TR, TE and a high flip angle greater than 60 degrees.
To some degree, in phasesequences are more sensitive to detection of focal hepatic lesions than out of phase for evaluating reduced lesion-to-liver contrast, but the choice for a T1 gradient echo sequence is still based on field strength, advanced imaging techniques (breath hold imaging), and physician preference.
Multiple echoes acquired in a gradient echo scan are combined into an image, for less artifacts and higher SNR; the early echoes provide increased SNR, whilst later echoes boost contrast. This sequence type is also known as MERGE (Multiple Echo Recombined Gradient Echo)