The term in phase refers to an image in which the signals from two spectral components (such as fat and water) add constructively in a voxel. T1 weighted in phase images are acquired by a gradient echo-based technique with a short TR, TE and a high flip angle greater than 60 degrees. To some degree, in phase sequences are more sensitive to detection of focal hepatic lesions than out of phase for evaluating reduced lesion-to-liver contrast, but the choice for a T1 gradient echo sequence is still based on field strength, advanced imaging techniques (breath hold imaging), and physician preference.

Quick Overview
Please note that there are different common names for this artifact.

Black boundary artifacts are black lines following voxels where both water and fat protons are present in the same voxel. This artifact arise along the boundary of organs or tissues perpendicular to the frequency encoding direction, and occurs preferentially in gradient echo sequences with out of phase echo times.

Fat suppression techniques eliminate this artifact. For artifact reducing helps a smaller water fat shift (high bandwidth), a higher matrix or/and an in phase TE.

See also Chemical Shift Artifact.

Quick Overview
Please note that there are different common names for this artifact.

During frequency encoding, fat protons precess slower than water protons in the same slice because of their magnetic shielding. Through the difference in resonance frequency between water and fat, protons at the same location are misregistrated (dislocated) by the Fourier transformation, when converting MRI signals from frequency to spatial domain. This chemical shift misregistration cause accentuation of any fat-water interfaces along the frequency axis and may be mistaken for pathology. Where fat and water are in the same location, this artifact can be seen as a bright or dark band at the edge of the anatomy.
Protons in fat and water molecules are separated by a chemical shift of about 3.5 ppm. The actual shift in Hertz (Hz) depends on the magnetic field strength of the magnet being used. Higher field strength increases the misregistration, while in contrast a higher gradient strength has a positive effect. For a 0.3 T system operating at 12.8 MHz the shift will be 44.8 Hz compared with a 223.6 Hz shift for a 1.5 T system operating at 63.9 MHz.

For artifact reduction helps a smaller water fat shift (higher bandwidth), a higher matrix, an in phase TE or a spin echo technique. Since the misregistration offset is present in the read out axis the patient may be rescanned with this axis parallel to the fat-water interface. Steeper gradient may be employed to reduce the chemical shift offset in mm. Another strategy is to employ specialized pulse sequences such as fat saturation or inversion recovery imaging. Fat suppression techniques eliminate chemical shift artifacts caused by the lack of fat signal.

See also Black Boundary Artifact and Magnetic Resonance Spectroscopy.

(DE FGRE, Dual/FFE, DE FFE) Simultaneously acquired in and out of phase TE gradient echo images. To quantitatively measure the signal intensity differences between out of phase and in phase images the parameters should be the same except for the TE.
The chemical shift artifact appearing on the out-of-phase image allows for the detection of lipids in the liver or adrenal gland, such as diffuse fatty infiltration, focal fatty infiltration, focal fatty sparing, benign adrenocortical masses and intracellular lipids within a hepatocellar neoplasm, where spin echo and fat suppression techniques are not as sensitive. Specific pathologies that have been reported include liver lipoma, angiomyolipoma, myelolipoma, metastatic liposarcoma, teratocarcinoma, melanoma, haemorrhagic neoplasm and metastatic choriocarcinoma.

(FESUM) See Gradient Recalled Echo Sequence and In Phase Image.