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Spectroscopy
 
Edward Purcell and Felix Bloch discovered the basic of spectroscopy in 1946 (see MRI History). Nuclear magnetic resonance spectroscopy (NMR Spectroscopy or MRS) is an analytical tool, based on nuclei that have a spin (nuclei with an odd number of neutrons and/or protons) like 1H, 13C, 17O, 19F, 31P etc.
Through nuclear magnetic principles as precession, chemical shift, spin spin coupling etc., the analysis of the content, purity, and molecular structure of a sample is possible. The spectrum produced by this process contains a number of peaks; the highs and the positions of these peaks allow the exact analysis. Unknown compounds can be matched against spectral libraries. Even very complex organic compounds as enzymes and proteins can be determined. For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different techniques available.
See Spectroscopic Imaging Techniques.
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Further Reading:
  Basics:
MR Spectroscopy May Help Avoid Invasive Procedures And Treatments For Recurrent Brain Lesions
Wednesday, 11 February 2009   by www.sciencedaily.com    
MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs
Monday, 9 September 2013   by phys.org    
  News & More:
Pioneering MRI imaging method captures brain glucose metabolism without the need for administration of radioactive substances
Friday, 28 April 2023   by www.eurekalert.org    
New quantum sensing technique allows high-resolution nuclear magnetic resonance spectroscopy
Wednesday, 17 June 2020   by phys.org    
MR Spectroscopy Detects Biochemical Alterations in Pre-Invasive Breast Cancer Patients
Wednesday, 11 March 2015   by radiationtherapynews.com    
MR Spectroscopy Shows Differences in Brains of Preterm Infants
Monday, 25 November 2013   by www.digitaljournal.com    
Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder.
Wednesday, 16 March 2011   by leftbrainrightbrain.co.uk    
Magnetic resonance spectroscopy for breast cancer
Wednesday, 11 July 2007   by www.news-medical.net    
MRI Resources 
Mass Spectrometry - Nerve Stimulator - Journals - Health - RIS - Shoulder MRI
 
Foreign BodiesMRI Resource Directory:
 - MRI Accidents -
 
mri safety guidance
MRI Safety Guidance
Occult incorporated ferromagnetic foreign bodies are dangerous, in particular those close to the eyes. The patient's history may help because many patients do not remember such accidents. In case of doubt, X-rays should be taken prior to MR imaging.
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MRI Resources 
Examinations - Non-English - Claustrophobia - Journals - Cardiovascular Imaging - Software
 
Nephrogenic Systemic FibrosisForum -
related threads
 
(NSF) Nephrogenic systemic fibrosis is a rare and highly debilitating disorder that involves extensive thickening and hardening of the skin with fibrotic nodules and plaques.
MRI contrast media have very low side effects, but accumulating data indicate that gadolinium-based contrast agents increase the risk for the development of NSF among patients with severe renal insufficiency or renal dysfunction due to the hepato-renal syndrome or in the perioperative liver transplantation period.
Due to this reason, gadolinium contrast agents are now considered contraindicated in patients with an estimated glomerular filtration rate fewer than 30 mL/min/1.73m2. In these patients, avoid use of gadolinium-based contrast agents unless the diagnostic information is essential and not available with non-contrast enhanced magnetic resonance imaging (MRI).

Recognized or possibly associated factors for NSF:
Severe renal failure;
high dose of gadolinium chelate;
high dose of erythropoietin;
high serum phosphate levels;
high serum calcium levels;
major surgery, infection, vascular event;
history of hypothyroidism;
metabolic acidosis.

When administering a gadolinium-based contrast agent, do not exceed the recommended dose and allow a sufficient period of time for elimination of the contrast medium from the body prior to any readminstration. Screen all patients for renal dysfunction by obtaining a history and/or laboratory tests.

See also Contrast Medium, Adverse Reaction, MRI Risks, MRI Safety, Ionic Intravenous Contrast Agents, Nonionic Intravenous Contrast Agents, and Contraindications.
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Further Reading:
  Basics:
Important Drug Warning for Gadolinium-Based Contrast Agents
Wednesday, 12 September 2007   by www.ismrm.org    
European Medicines Agency makes recommendations to minimise risk of nephrogenic systemic fibrosis with gadolinium-containing contrast agents
Friday, 20 November 2009   by www.ema.europa.eu    
Gadolinium-based MR Contrast Agents and Nephrogenic Systemic Fibrosis
Thursday, 1 March 2007   by radiology.rsna.org    
NSF-Active and NSF-Inert Species of Gadolinium: Mechanistic and Clinical Implications
Friday, 27 June 2008   by www.ajronline.org    
  News & More:
Questions and Answers on Gadolinium-Based Contrast Agents
Friday, 9 January 2009   by www.fda.gov    
Searchterm 'MRI History' was also found in the following service: 
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Breast MRIMRI Resource Directory:
 - Breast MRI -
 
(MR mammography) Magnetic resonance imaging of the breast is particularly useful in evaluation of newly diagnosed breast cancer, in women whose breast tissue is mammographically very dense and for screening in women with a high lifetime risk of breast cancer because of their family history or genetic disposition.
Breast MRI can be performed on all standard whole body magnets at a field strength of 0.5 T - 1.5 Tesla. Powerful gradient strengths over 15 mT/m will help to improve the balance between spatial resolution, scanning speed, and volume coverage. The use of a dedicated bilateral breast coil is obligatory.
Malignant lesions release angiogenic factors that increase local vessel density and vessel permeability. Breast cancer is detectable due to the strong enhancement in dynamic breast imaging that peaks early (about 1-2 min.) after contrast medium injection. If breast cancer is suspected, a breast biopsy may be necessary to secure the diagnosis.

See also Magnetic Resonance Imaging MRI, Biopsy and MR Guided Interventions.

Requirements in breast MRI procedures:
•
Both breasts must be measured without gaps.
•
Temporal resolution should be sufficient to allow early imaging after contrast agent with dynamic imaging every 60-120 sec.
•
For the best possible detection of enhancement fat signal should be eliminated either by image subtraction or by spectrally selective fat saturation.
•
Thin slices are necessary to assure absence of partial volume effects.
•
Imaging should be performed with a spatial resolution in plane less than 1 mm.

For Ultrasound Imaging (USI) see Breast Ultrasound at Medical-Ultrasound-Imaging.com.

See also the related poll result: 'MRI will have replaced 50% of x-ray exams by'
 
Images, Movies, Sliders:
 Breast MRI Images T2 And T1  Open this link in a new window
      
 Breast MRI Images T2 And T1 Pre - Post Contrast  Open this link in a new window
 Breast MRI Images T1 Pre - Post Contrast  Open this link in a new window
      
 
Radiology-tip.comradMammography,  Breast Imaging
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Medical-Ultrasound-Imaging.comBreast Ultrasound
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• View the DATABASE results for 'Breast MRI' (13).Open this link in a new window


• View the NEWS results for 'Breast MRI' (41).Open this link in a new window.
 
Further Reading:
  Basics:
New Screening Guidelines for Women at High Risk for Breast Cancer
Wednesday, 26 September 2007   by www.newswise.com    
CONTRAST-ENHANCED MRI OF THE BREAST(.pdf)
MRI Improves Breast Cancer Screening in Older BRCA Carriers
Monday, 5 January 2015   by www.cancernetwork.com    
  News & More:
Technology advances in breast cancer screenings lead to early diagnosis
Friday, 6 October 2023   by ksltv.com    
Are synthetic contrast-enhanced breast MRI images as good as the real thing?
Friday, 18 November 2022   by healthimaging.com    
Abbreviated breast MRI protocols not as cost-effective as promised, new study shows
Wednesday, 20 July 2022   by healthimaging.com    
Deep learning poised to improve breast cancer imaging
Thursday, 24 February 2022   by www.eurekalert.org    
Pre-Operative Breast MRI Can Help Identify Patients Likely to Experience Nipple-Sparing Mastectomy Risks
Wednesday, 7 April 2021   by www.diagnosticimaging.com    
Breast cancer screening recalls: simple MRI measurement could avoid 30% of biopsies
Monday, 1 March 2021   by www.eurekalert.org    
A Comparison of Methods for High-Spatial-Resolution Diffusion-weighted Imaging in Breast MRI
Tuesday, 25 August 2020   by pubs.rsna.org    
Pre-Operative Breast MRI Diagnoses More Cancers in Women with DCIS
Thursday, 9 July 2020   by www.diagnosticimaging.com    
Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer
Thursday, 26 December 2019   by cancerimagingjournal.biomedcentral.com    
Breast MRI Coding Gets an Overhaul in 2019
Wednesday, 9 January 2019   by www.aapc.com    
How accurate are volumetric software programs when compared to breast MRI?
Thursday, 27 July 2017   by www.radiologybusiness.com    
Additional Breast Cancer Tumors Found on MRI After Mammography May Be Larger, More Aggressive
Wednesday, 9 December 2015   by www.oncologynurseadvisor.com    
Preoperative MRI May Overdiagnose Contralateral Breast Cancer
Wednesday, 2 December 2015   by www.cancertherapyadvisor.com    
BI-RADS and breast MRI useful in predicting malignancy
Wednesday, 30 May 2012   by www.oncologynurseadvisor.com    
MRI Resources 
Equipment - NMR - Societies - Crystallography - MRI Technician and Technologist Career - Claustrophobia
 
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