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Nuclear Magnetic ResonanceMRI Resource Directory:
 - NMR -
 
(NMR) Nuclear Magnetic Resonance is a physical phenomenon of the magnetic property of nuclei, which have a positive nuclear spin quantum number.
Under the influence of an external static magnetic field this nuclei will precess about the direction of the magnetic field with an angular frequency (Larmor frequency). Through absorption and emission of RF energy (gradients, RF coils) at the resonance frequency (Larmor equation) and the processing of this raw data by the Fourier transformation - physical, chemical, electronic, and structural information about molecules can be obtained (NMR Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging).
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• View the NEWS results for 'Nuclear Magnetic Resonance' (1).Open this link in a new window.
 
Further Reading:
  Basics:
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
Nuclear magnetic resonance with no magnets
Wednesday, 18 May 2011   by www.physorg.com    
  News & More:
Neuromelanin-Sensitive MRI Identified as a Potential Biomarker for Psychosis
Sunday, 10 February 2019   by www.nimh.nih.gov    
A powder to enhance NMR signals
Thursday, 12 December 2013   by phys.org    
New Paradigm for Nanoscale Resolution MRI Experimentally Achieved
Friday, 27 September 2013   by www.sciencedaily.com    
Searchterm 'Magnetic Resonance Spectroscopy' was also found in the following service: 
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Radiology  (1) Open this link in a new window
Sensitive Point
 
The sensitive point in an object (or a region) is the point from which information is being measured, as in sequential point imaging or in single voxel MR spectroscopy sequential point imaging used. To define a sensitive point, it must be selected in three dimensions. Different combinations of selective excitation, inversion, or saturation pulses can be used. Sometimes, combinations of two or more measurements are necessary to define the sensitive point (or volume).

See also Magnetic Resonance Spectroscopy.
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MRI Resources 
MRI Centers - Colonography - Software - Education pool - Breast Implant - Most Wanted
 
Spectroscopy
 
Edward Purcell and Felix Bloch discovered the basic of spectroscopy in 1946 (see MRI History). Nuclear magnetic resonance spectroscopy (NMR Spectroscopy or MRS) is an analytical tool, based on nuclei that have a spin (nuclei with an odd number of neutrons and/or protons) like 1H, 13C, 17O, 19F, 31P etc.
Through nuclear magnetic principles as precession, chemical shift, spin spin coupling etc., the analysis of the content, purity, and molecular structure of a sample is possible. The spectrum produced by this process contains a number of peaks; the highs and the positions of these peaks allow the exact analysis. Unknown compounds can be matched against spectral libraries. Even very complex organic compounds as enzymes and proteins can be determined. For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different techniques available.
See Spectroscopic Imaging Techniques.
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Further Reading:
  Basics:
MR Spectroscopy May Help Avoid Invasive Procedures And Treatments For Recurrent Brain Lesions
Wednesday, 11 February 2009   by www.sciencedaily.com    
MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs
Monday, 9 September 2013   by phys.org    
  News & More:
Pioneering MRI imaging method captures brain glucose metabolism without the need for administration of radioactive substances
Friday, 28 April 2023   by www.eurekalert.org    
New quantum sensing technique allows high-resolution nuclear magnetic resonance spectroscopy
Wednesday, 17 June 2020   by phys.org    
MR Spectroscopy Detects Biochemical Alterations in Pre-Invasive Breast Cancer Patients
Wednesday, 11 March 2015   by radiationtherapynews.com    
MR Spectroscopy Shows Differences in Brains of Preterm Infants
Monday, 25 November 2013   by www.digitaljournal.com    
Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder.
Wednesday, 16 March 2011   by leftbrainrightbrain.co.uk    
Magnetic resonance spectroscopy for breast cancer
Wednesday, 11 July 2007   by www.news-medical.net    
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MRI History
 
•
Sir Joseph Larmor (1857-1942) developed the equation that the angular frequency of precession of the nuclear spins being proportional to the strength of the magnetic field. [Larmor relationship]
•
In the 1930's, Isidor Isaac Rabi (Columbia University) succeeded in detecting and measuring single states of rotation of atoms and molecules, and in determining the mechanical and magnetic moments of the nuclei.
•
Felix Bloch (Stanford University) and Edward Purcell (Harvard University) developed instruments, which could measure the magnetic resonance in bulk material such as liquids and solids. (Both honored with the Nobel Prize for Physics in 1952.) [The birth of the NMR spectroscopy]
•
In the early 70's, Raymond Damadian (State University of New York) demonstrated with his NMR device, that there are different T1 relaxation times between normal and abnormal tissues of the same type, as well as between different types of normal tissues.
•
In 1973, Paul Lauterbur (State University of New York) described a new imaging technique that he termed Zeugmatography. By utilizing gradients in the magnetic field, this technique was able to produce a two-dimensional image (back-projection). (Through analysis of the characteristics of the emitted radio waves, their origin could be determined.) Peter Mansfield further developed the utilization of gradients in the magnetic field and the mathematically analysis of these signals for a more useful imaging technique. (Paul C Lauterbur and Peter Mansfield were awarded with the 2003 Nobel Prize in Medicine.)
•
In 1975, Richard Ernst introduced 2D NMR using phase and frequency encoding, and the Fourier Transform. Instead of Paul Lauterbur's back-projection, he timely switched magnetic field gradients ('NMR Fourier Zeugmatography'). [This basic reconstruction method is the basis of current MRI techniques.]
•
1977/78: First images could be presented. A cross section through a finger by Peter Mansfield and Andrew A. Maudsley. Peter Mansfield also could present the first image through the abdomen.
•
In 1977, Raymond Damadian completed (after 7 years) the first MR scanner (Indomitable). In 1978, he founded the FONAR Corporation, which manufactured the first commercial MRI scanner in 1980. Fonar went public in 1981.
•
1981: Schering submitted a patent application for Gd-DTPA dimeglumine.
•
1982: The first 'magnetization-transfer' imaging by Robert N. Muller.
•
In 1983, Toshiba obtained approval from the Ministry of Health and Welfare in Japan for the first commercial MRI system.
•
In 1984, FONAR Corporation receives FDA approval for its first MRI scanner.
•
1986: Jürgen Hennig, A. Nauerth, and Hartmut Friedburg (University of Freiburg) introduced RARE (rapid acquisition with relaxation enhancement) imaging. Axel Haase, Jens Frahm, Dieter Matthaei, Wolfgang Haenicke, and Dietmar K. Merboldt (Max-Planck-Institute, Göttingen) developed the FLASH (fast low angle shot) sequence.
•
1988: Schering's MAGNEVIST gets its first approval by the FDA.
•
In 1991, fMRI was developed independently by the University of Minnesota's Center for Magnetic Resonance Research (CMRR) and Massachusetts General Hospital's (MGH) MR Center.
•
From 1992 to 1997 Fonar was paid for the infringement of it's patents from 'nearly every one of its competitors in the MRI industry including giant multi-nationals as Toshiba, Siemens, Shimadzu, Philips and GE'.
•
 
Images, Movies, Sliders:
 Cardiac Infarct Short Axis Cine Overview  Open this link in a new window
    

Courtesy of  Robert R. Edelman
 
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• View the NEWS results for 'MRI History' (1).Open this link in a new window.
 
Further Reading:
  Basics:
Magnetic Resonance Imaging, History & Introduction
2000   by www.cis.rit.edu    
A Short History of the Magnetic Resonance Imaging (MRI)
   by www.teslasociety.com    
Fonar Our History
   by www.fonar.com    
  News & More:
Scientists win Nobels for work on MRI
Tuesday, 10 June 2003   by usatoday30.usatoday.com    
2001 Lemelson-MIT Lifetime Achievement Award Winner
   by web.mit.edu    
MRI's inside story
Thursday, 4 December 2003   by www.economist.com    
Searchterm 'Magnetic Resonance Spectroscopy' was also found in the following service: 
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Radiology  (1) Open this link in a new window
Signa HDx 1.5T™InfoSheet: - Devices -
Intro, 
Types of Magnets, 
Overview, 
etc.
 
www.vitalcom.com/euen/mri/products/signa-hdx-15t/index.html From GE Healthcare;
The GE Signa HDx MRI system is a whole body magnetic resonance scanner designed to support high resolution, high signal to noise ratio, and short scan times.
The 1.5T Signa HDx MR Systems is a modification of the currently marketed GE 1.5T machines, with the main difference being the change to the receive chain architecture that includes a thirty two independent receive channels, and allows for future expansion in 16 channel increments. The overall system has been improved with a simplified user interface and a single 23" liquid crystal display, improved multi channel surface coil connectivity, and an improved image reconstruction architecture known as the Volume Recon Engine (VRE).
Device Information and Specification
CLINICAL APPLICATION
Whole body
CONFIGURATION
Compact short bore
Possible
SYNCHRONIZATION
ECG/peripheral, respiratory gating, (SmartPrep, SmartStep)
PULSE SEQUENCES
Standard: SE, IR, 2D/3D GRE and SPGR, Angiography: 2D/3D TOF, 2D/3D Phase Contrast; 2D/3D FSE, 2D/3D FGRE and FSPGR, SSFP, FLAIR, EPI, optional: 2D/3D Fiesta, FGRET, Spiral, Tensor,
IMAGING MODES
2D single slice, multi slice, and 3D volume images, multi slab, cine
1 cm to 48 cm continuous
2D 0.7 mm to 20 mm; 3D 0.1 mm to 5 mm
1028 x 1024
MEASURING MATRIX
128x512 steps 32 phase encode
PIXEL INTENSITY
256 gray levels
POWER REQUIREMENTS
480 or 380/415
COOLING SYSTEM TYPE
Closed-loop water-cooled gradient
CRYOGEN USE, L/hr
less than 0.03 L/hr liquid helium
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