(MT)
Magnetization Transfer was accidentally discovered by Wolff and Balaban in 1989. Conventional
MRI is based on the differences in T1, T2 and the
proton density (water content and the mobility of water molecules) in tissue; it relies primarily on free (bulk) water protons. The
T2 relaxation times are greater than 10 ms and detectable. The
T2 relaxation times of protons associated with macromolecules are less then 1 ms and not detectable in
MRI.
Magnetization Transfer Imaging (MTI) is based on the
magnetization interaction (through dipolar and/or chemical exchange) between bulk water protons and macromolecular protons. By applying an
off resonance radio frequency pulse to the macromolecular protons, the
saturation of these protons is then transferred to the bulk water protons. The result is a decrease in signal (the net
magnetization of visible protons is reduced), depending on the
magnitude of MT between tissue macromolecules and bulk water. With MTI, the presence or absence of macromolecules (e.g. in membranes,
brain tissue) can be seen.
The
magnetization transfer ratio (MTR) is the difference in
signal intensity with or without MT.
See also
Magnetization Transfer Contrast.