Porphyrins occur naturally in plants and animals. All porphyrin molecules feature an aromatic macrocycle ring with a central binding site. This site accommodates transition metals, which are held in place by inward-facing nitrogen atoms. Metalloporphyrins have usually a low toxicity and a potential of a selective uptake in tumors or necrosis. These properties are advantageous for a use as MRI tumor specific agents with positive enhancement. These contrast agents enhance tumors on T1 weighted sequences, which are isointense to surrounding tissues. Porphyrin-based compounds have also necrosis avid properties; they can depict the extent of myocardial infarction as defined by histopathology.
Metalloporphyrins are also used in photodynamic therapy of tumors. The compounds contain a 'lone star' metal atom at the center of the ring and are 'bigger than the average porphyrin'. They contain five N atoms in the central chelating core and this allows them to form complexes with large trivalent lanthanide metals, which have useful cancer therapy properties.

See also Classifications, Characteristics, etc., Gadophrin, MnIIITPPS4, Necrosis Avid Contrast Agent.

Short name: NC100150, PEG-feron, generic name: Feruglose, preliminary trade name: Clariscanâ„¢
NC100150 injection is the code name for an USPIO (ultrasmall superparamagnetic iron oxide) MRI contrast agent under development. Microvessel permeability depends on functional and morphologic characteristics of cancer vessels and on physicochemical properties of the injected contrast medium molecule.
USPIO particles have a favorable pharmacological and tolerance profile and are being tested clinically of the potential for the quantitative characterization of tumor microvasculature and specifically for measures of the microvessel permeability. Iron-based products take advantage of their large molecular size, which prevents diffusion into body tissues. These agents are disposed of by the liver and spleen as particulate matter.
NC100150 Injection (Nycomed Amersham, Amersham Health ) consists of USPIO particles that are composed of single crystals (4- to 7-nm diameter) and stabilized with a carbohydrate polyethylene glycol (PEG) coat. The iron oxide particles have to be suspended in an isotonic glucose solution. The final diameter of an USPIO particle is approximately 20 nm. Blood pool half-life is more than two hours in humans; the particles are taken up by the mononuclear phagocyte system and distributed mainly to the liver and spleen.
NC100150 would compete with the contrast agents Ferumoxytol from AMAG Pharmaceuticals, Inc. and Vasovistâ„¢ from EPIX Pharmaceuticals, Inc., but at this time the development of NC100150 Injection/Clariscan™ is discontinued.

(NMR) Nuclear Magnetic Resonance is a physical phenomenon of the magnetic property of nuclei, which have a positive nuclear spin quantum number.
Under the influence of an external static magnetic field this nuclei will precess about the direction of the magnetic field with an angular frequency (Larmor frequency). Through absorption and emission of RF energy (gradients, RF coils) at the resonance frequency (Larmor equation) and the processing of this raw data by the Fourier transformation - physical, chemical, electronic, and structural information about molecules can be obtained (NMR Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging).

Substances exhibiting paramagnetic properties are used as contrast agents in MR imaging. They have a small but positive magnetic susceptibility (magnetizability - tends to align along the magnetic field). Typical paramagnetic substances usually possess an unpaired electron and include atoms or ions of transition elements, rare earth elements, some metals, and some molecules including molecular oxygen and free radicals.

See also Paramagnetism.

Any molecule used to measure organ perfusion in conjunction with imaging.
Characteristics of good perfusion agents:
Perfusion agents used in MRI are small Gd-chelates (they do not cross blood brain barrier, but extravasate quickly into extracellular space in other organs) and SPIOS.