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News  (37)  Resources  (12)  
 
Molecular Imaging
 
Molecular Imaging is a new diagnostic discipline to visualize biological processes.
Molecular magnetic resonance imaging (mMRI) offers the potential to image tissues at the cellular and subcellular level. Targeted MR contrast agents enhance the diagnostic specificity and range of molecular magnetic resonance imaging.
Other modalities that can be used for noninvasive molecular imaging:
•
Ultrasound;
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optical imaging;
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positron emission tomography (PET);
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single photon emission computed tomography (SPECT).


See also Nanoparticle, Monocrystalline Iron Oxide Nanoparticle, Polycrystalline Iron Oxide Nanoparticles, Liposomes, Monoclonal Antibodies, Bimodal Imaging, Tumor Specific Agents, and Intracellular Contrast Agents.
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• View the NEWS results for 'Molecular Imaging' (28).Open this link in a new window.
 
Further Reading:
  Basics:
Multimodal Nanoparticles for Quantitative Imaging(.pdf)
Tuesday, 13 December 2011   by alexandria.tue.nl    
Molecular Magnetic Resonance Imaging(.pdf)
2005   by www.medical.siemens.com    
  News & More:
Smarter MRI diagnosis with nano MRI lamp
Monday, 6 February 2017   by www.eurekalert.org    
Molecular MRI technique gives early indication of cancer treatment effectiveness
Monday, 11 April 2016   by www.healthimaging.com    
Molecular imaging and radiochemistry: the importance of instrumentation. An interview with Professor Bjorn Wangler
Thursday, 4 February 2016   by www.news-medical.net    
Positron Emission Tomographic Imaging in Stroke
Monday, 28 December 2015   by www.ncbi.nlm.nih.gov    
Potential and Limitations of Oxygen-17 MR Perfusion Measurements
Monday, 1 March 2004   by www.case.edu    
MRI Resources 
Brain MRI - Used and Refurbished MRI Equipment - Mobile MRI Rental - Musculoskeletal and Joint MRI - Libraries - Portals
 
Chemical Shift ArtifactInfoSheet: - Artifacts - 
Case Studies, 
Reduction Index, 
etc.MRI Resource Directory:
 - Artifacts -
 
Quick Overview
Please note that there are different common names for this artifact.
Artifact Information
NAME
Chemical shift, black boundary, spatial misregistration, relief
DESCRIPTION
Black or bright band
During frequency encoding, fat protons precess slower than water protons in the same slice because of their magnetic shielding. Through the difference in resonance frequency between water and fat, protons at the same location are misregistrated (dislocated) by the Fourier transformation, when converting MRI signals from frequency to spatial domain. This chemical shift misregistration cause accentuation of any fat-water interfaces along the frequency axis and may be mistaken for pathology. Where fat and water are in the same location, this artifact can be seen as a bright or dark band at the edge of the anatomy.
Protons in fat and water molecules are separated by a chemical shift of about 3.5 ppm. The actual shift in Hertz (Hz) depends on the magnetic field strength of the magnet being used. Higher field strength increases the misregistration, while in contrast a higher gradient strength has a positive effect. For a 0.3 T system operating at 12.8 MHz the shift will be 44.8 Hz compared with a 223.6 Hz shift for a 1.5 T system operating at 63.9 MHz.
mri safety guidance
Image Guidance
For artifact reduction helps a smaller water fat shift (higher bandwidth), a higher matrix, an in phase TE or a spin echo technique. Since the misregistration offset is present in the read out axis the patient may be rescanned with this axis parallel to the fat-water interface. Steeper gradient may be employed to reduce the chemical shift offset in mm. Another strategy is to employ specialized pulse sequences such as fat saturation or inversion recovery imaging. Fat suppression techniques eliminate chemical shift artifacts caused by the lack of fat signal.

See also Black Boundary Artifact and Magnetic Resonance Spectroscopy.
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• View the DATABASE results for 'Chemical Shift Artifact' (7).Open this link in a new window

 
Further Reading:
  Basics:
MRI Artifact Gallery
   by chickscope.beckman.uiuc.edu    
  News & More:
What is chemical shift artefact? Why does it occur? How many Hz at 1.5 T?
   by www.revisemri.com    
Abdominal MRI at 3.0 T: The Basics Revisited
Wednesday, 20 July 2005   by www.ajronline.org    
MRI Resources 
MRI Accidents - Pediatric and Fetal MRI - - Software - Quality Advice - Fluorescence
 
MRI SafetyMRI Resource Directory:
 - Safety -
 
There are different types of contraindications that would prevent a person from being examined with an MRI scanner. MRI systems use strong magnetic fields that attract any ferromagnetic objects with enormous force. Caused by the potential risk of heating, produced from the radio frequency pulses during the MRI procedure, metallic objects like wires, foreign bodies and other implants needs to be checked for compatibility. High field MRI requires particular safety precautions. In addition, any device or MRI equipment that enters the magnet room has to be MR compatible. MRI examinations are safe and harmless, if these MRI risks are observed and regulations are followed.

Safety concerns in magnetic resonance imaging include:
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the magnetic field strength;
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possible 'missile effects' caused by magnetic forces;
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the potential for heating of body tissue due to the application of the radio frequency energy;
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the effects on implanted active devices such as cardiac pacemakers or insulin pumps;
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magnetic torque effects on indwelling metal (clips, etc.);
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the audible acoustic noise;
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danger due to cryogenic liquids;
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the application of contrast medium;
mri safety guidance
MRI Safety Guidance
It is important to remember when working around a superconducting magnet that the magnetic field is always on. Under usual working conditions the field is never turned off. Attention must be paid to keep all ferromagnetic items at an adequate distance from the magnet. Ferromagnetic objects which came accidentally under the influence of these strong magnets can injure or kill individuals in or nearby the magnet, or can seriously damage every hardware, the magnet itself, the cooling system, etc.. See MRI resources Accidents.
The doors leading to a magnet room should be closed at all times except when entering or exiting the room. Every person working in or entering the magnet room or adjacent rooms with a magnetic field has to be instructed about the dangers. This should include the patient, intensive-care staff, and maintenance-, service- and cleaning personnel, etc..
The 5 Gauss limit defines the 'safe' level of static magnetic field exposure. The value of the absorbed dose is fixed by the authorities to avoid heating of the patient's tissue and is defined by the specific absorption rate. Leads or wires that are used in the magnet bore during imaging procedures, should not form large-radius wire loops. Leg-to-leg and leg-to-arm skin contact should be prevented in order to avoid the risk of burning due to the generation of high current loops if the legs or arms are allowed to touch. The patient's skin should not be in contact with the inner bore of the magnet.
The outflow from cryogens like liquid helium is improbable during normal operation and not a real danger for patients.
The safety of MRI contrast agents is tested in drug trials and they have a high compatibility with very few side effects. The variations of the side effects and possible contraindications are similar to X-ray contrast medium, but very rare. In general, an adverse reaction increases with the quantity of the MRI contrast medium and also with the osmolarity of the compound.

See also 5 Gauss Fringe Field, 5 Gauss Line, Cardiac Risks, Cardiac Stent, dB/dt, Legal Requirements, Low Field MRI, Magnetohydrodynamic Effect, MR Compatibility, MR Guided Interventions, Claustrophobia, MRI Risks and Shielding.
Radiology-tip.comradRadiation Safety,  Ionizing Radiation
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Medical-Ultrasound-Imaging.comUltrasound Safety,  Absorbed Dose
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• View the DATABASE results for 'MRI Safety' (42).Open this link in a new window


• View the NEWS results for 'MRI Safety' (13).Open this link in a new window.
 
Further Reading:
  Basics:
MRI Safety
2001   by www.fda.gov    
What MRI Sequences Produce the Highest Specific Absorption Rate (SAR), and Is There Something We Should Be Doing to Reduce the SAR During Standard Examinations?
Thursday, 16 April 2015   by www.ajronline.org    
Contrast Agents: Safety Profile
   by www.clinical-mri.com    
  News & More:
How safe is 7T MRI for patients with neurosurgical implants?
Thursday, 17 November 2022   by healthimaging.com    
Newer Heart Devices Safe During MRI
Monday, 23 August 2004   by www.hospimedica.com    
Study: Face Masks Unsafe in MRI Machines
Wednesday, 13 July 2022   by www.laboratoryequipment.com    
COVID-19: Attention shifts to MRI infection control
Thursday, 9 July 2020   by https://www.auntminnieeurope.com/index.aspx?sec=ser§sub=def§pag=dis§ItemID=619012    
FDA Releases New Guidance On Establishing Safety, Compatibility Of Passive Implants In MR Environments
Tuesday, 16 December 2014   by www.meddeviceonline.com    
Modern Implantable Heart Devices Safe For Use In MRI Scans
Wednesday, 16 March 2005   by www.sciencedaily.com    
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MRI is trending to low field magnets :
reduced costs will lead to this change 
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