(fMRI) Functi
onal
magnetic resonance imaging is a technique used to determine the dynamic
brain functi
on, often based
on echo planar imaging, but can also be performed by using
contrast agents and observing their first pass effects through
brain tissue. Functi
onal
magnetic resonance imaging allows insights in a dysfuncti
onal
brain as well as into the basic workings of the
brain.
The in functi
onal
brain MRI most frequently used effect to assess
brain functi
on is the
blood oxygenation level dependent contrast (
BOLD) effect, in which
differential changes in
brain perfusi
on and their resultant effect
on the regi
onal distributi
on of oxy- to deoxyhaemoglobin are observable because of the different 'intrinsic
contrast media' effects of the two
haemoglobin forms. Increased
brain activity causes an increased demand for oxygen, and the vascular system actually overcompensates for this, increasing the amount of oxygenated
haemoglobin. Because deoxygenated
haemoglobin attenuates the MR signal, the vascular resp
onse leads to a signal increase that is related to the neural activity.
Functi
onal imaging relates body functi
on or thought to specific locati
ons where the neural activity is taking place. The
brain is scanned at low
resolution but at a fast rate (typically
once every 2-3 sec
onds). Structural
MRI together with fMRI provides an anatomical
baseline and best
spatial resolution.
Interacti
ons can also be seen from the motor cortex to the cerebellum or basal ganglia in the case of a movement disorder such as ataxia. For example: by a finger movement the briefly increase in the blood circulati
on of the appropriate part of the
brain c
ontrolling that movement, can be measured.