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Result : Searchterm 'Peak' found in 4 terms [] and 18 definitions []
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Full Width at Tenth Maximum
 
(FWTM) The width of a Gaussian or Lorentzian type curve at the tenth of its maximum height (full width at half maximum (FWHM)) and a quality measure of the sharpness of a peak (frequency peak, resolution peak) used less frequently than the FWHM measure.
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Lorentzian Line
 
Usual shape of the lines in a NMR spectrum, characterized by a central peak with long tails; proportional to 1/[(1/T2)2 + (f - fo)2], where f is frequency and fo is the frequency of the peak (i.e., central resonance frequency). A Lorentzian function is the Fourier transformation of a decaying exponential.
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Magnetic Resonance SpectroscopyMRI Resource Directory:
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(MRS / MRSI - Magnetic Resonance Spectroscopic Imaging) A method using the NMR phenomenon to identify the chemical state of various elements without destroying the sample. MRS therefore provides information about the chemical composition of the tissues and the changes in chemical composition, which may occur with disease processes.
Although MRS is primarily employed as a research tool and has yet to achieve widespread acceptance in routine clinical practice, there is a growing realization that a noninvasive technique, which monitors disease biochemistry can provide important new information for the clinician.
The underlying principle of MRS is that atomic nuclei are surrounded by a cloud of electrons, which very slightly shield the nucleus from any external magnetic field. As the structure of the electron cloud is specific to an individual molecule or compound, then the magnitude of this screening effect is also a characteristic of the chemical environment of individual nuclei.
In view of the fact that the resonant frequency is proportional to the magnetic field that it experiences, it follows that the resonant frequency will be determined not only by the external applied field, but also by the small field shift generated by the electron cloud. This shift in frequency is called the chemical shift (see also Chemical Shift). It should be noted that chemical shift is a very small effect, usually expressed in ppm of the main frequency. In order to resolve the different chemical species, it is therefore necessary to achieve very high levels of homogeneity of the main magnetic field B0. Spectra from humans usually require shimming the magnet to approximately one part in 100. High resolution spectra of liquid samples demand a homogeneity of about one part in 1000.
In addition to the effects of factors such as relaxation times that can affect the NMR signal, as seen in magnetic resonance imaging, effects such as J-modulation or the transfer of magnetization after selective excitation of particular spectral lines can affect the relative strengths of spectral lines.
In the context of human MRS, two nuclei are of particular interest - H-1 and P-31. (PMRS - Proton Magnetic Resonance Spectroscopy) PMRS is mainly employed in studies of the brain where prominent peaks arise from NAA, choline containing compounds, creatine and creatine phosphate, myo-inositol and, if present, lactate; phosphorus 31 MR spectroscopy detects compounds involved in energy metabolism (creatine phosphate, adenosine triphosphate and inorganic phosphate) and certain compounds related to membrane synthesis and degradation. The frequencies of certain lines may also be affected by factors such as the local pH. It is also possible to determine intracellular pH because the inorganic phosphate peak position is pH sensitive.
If the field is uniform over the volume of the sample, "similar" nuclei will contribute a particular frequency component to the detected response signal irrespective of their individual positions in the sample. Since nuclei of different elements resonate at different frequencies, each element in the sample contributes a different frequency component. A chemical analysis can then be conducted by analyzing the MR response signal into its frequency components.

See also Spectroscopy.
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Further Reading:
  News & More:
Accuracy of Proton Magnetic Resonance Spectroscopy in Distinguishing Neoplastic From Non-neoplastic Brain Lesions
Saturday, 2 December 2023   by www.cureus.com    
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Spectroscopy
 
Edward Purcell and Felix Bloch discovered the basic of spectroscopy in 1946 (see MRI History). Nuclear magnetic resonance spectroscopy (NMR Spectroscopy or MRS) is an analytical tool, based on nuclei that have a spin (nuclei with an odd number of neutrons and/or protons) like 1H, 13C, 17O, 19F, 31P etc.
Through nuclear magnetic principles as precession, chemical shift, spin spin coupling etc., the analysis of the content, purity, and molecular structure of a sample is possible. The spectrum produced by this process contains a number of peaks; the highs and the positions of these peaks allow the exact analysis. Unknown compounds can be matched against spectral libraries. Even very complex organic compounds as enzymes and proteins can be determined. For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different techniques available.
See Spectroscopic Imaging Techniques.
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Further Reading:
  Basics:
MR Spectroscopy May Help Avoid Invasive Procedures And Treatments For Recurrent Brain Lesions
Wednesday, 11 February 2009   by www.sciencedaily.com    
MRI spectroscopy is highly sensitive for lipid-soluble metabolites from UC-MSCs
Monday, 9 September 2013   by phys.org    
  News & More:
Pioneering MRI imaging method captures brain glucose metabolism without the need for administration of radioactive substances
Friday, 28 April 2023   by www.eurekalert.org    
New quantum sensing technique allows high-resolution nuclear magnetic resonance spectroscopy
Wednesday, 17 June 2020   by phys.org    
MR Spectroscopy Detects Biochemical Alterations in Pre-Invasive Breast Cancer Patients
Wednesday, 11 March 2015   by radiationtherapynews.com    
MR Spectroscopy Shows Differences in Brains of Preterm Infants
Monday, 25 November 2013   by www.digitaljournal.com    
Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder.
Wednesday, 16 March 2011   by leftbrainrightbrain.co.uk    
Magnetic resonance spectroscopy for breast cancer
Wednesday, 11 July 2007   by www.news-medical.net    
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Acoustic Noise
 
Vibrations of the gradient coil support structure create sound waves. These are caused by the interactions of the magnetic field created by pulses of the current through the gradient coil with the main magnetic field in a manner similar to a loudspeaker coil. The sounds made by the scanner vary in volume and tone with the type of procedure being performed.
Sound pressure is reported on a logarithmic scale called sound-pressure level, expressed in decibel (dB) referenced to the weakest audible 1 000 Hz sound pressure of 2 * 10-5 pascal (20 micropascal). Sound level meters contain filters that simulate the ear's frequency response. The most commonly used filter provides what is called 'A' weighting, with the letter 'A' appended to the dB units, i.e. dBA.
MRI system noise levels increase with field strength. Disposable earplugs and/or headphones for the patient are recommended in high-field systems. Noise-canceling systems and special earphones are available, and active acoustic control systems were developed, e.g. softtone, pianissimo. A sequence with low noise gradient pulses is also called 'whisper sequence'.

See also Phon and Decibel.
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Further Reading:
  Basics:
MRI Noise in Utero Not Harmful for Baby's Ears
Tuesday, 28 September 2010   by www.medgadget.com    
  News & More:
Noise from Magnetic Resonance Imaging Can Have Short-Term Impact on Hearing
Thursday, 22 February 2018   by www.diagnosticimaging.com    
Echo Planar Imaging at 4 Tesla With Minimum Acoustic Noise(.pdf)
   by www.bnl.gov    
TOSHIBA SHOWCASES PATIENT-FRIENDLY 3T MR SYSTEM
Sunday, 29 November 2009   by medical.toshiba.com    
MRI Resources 
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