Atomic nuclei that contain the same number of protons, but differ in the number of neutrons in the nucleus of the atom for the element concerned. For example, 1H, 2H, and 3H are the three isotopes of hydrogen, otherwise known as proton, deuterium, and tritium. Various isotopes have different nuclear magnetic moments and different resonant frequencies. Many isotopes have no magnetic moment and are therefore not observable by MR.

See also Isomer.

The T1 time constant, which determines the rate at which excited protons return to equilibrium within the lattice. The longitudinal relaxation time is a measure of the time taken for spinning protons to realign with the external magnetic field. The magnetization will grow after excitation from zero to a value of about 63% of its final value in a time of T1.

See also T1 Time.

(MRI) Magnetic resonance imaging is a noninvasive medical imaging technique that uses the interaction between radio frequency pulses, a strong magnetic field and body tissue to obtain images of slices/planes from inside the body. These magnets generate fields from approx. 2000 times up to 30000 times stronger than that of the Earth. The use of nuclear magnetic resonance principles produces extremely detailed pictures of the body tissue without the need for x-ray exposure and gives diagnostic information of various organs.
Measured are mobile hydrogen nuclei (protons are the hydrogen atoms of water, the 'H' in H20), the majority of elements in the body. Only a small part of them contribute to the measured signal, caused by their different alignment in the magnetic field. Protons are capable of absorbing energy if exposed to short radio wave pulses (electromagnetic energy) at their resonance frequency. After the absorption of this energy, the nuclei release this energy so that they return to their initial state of equilibrium.
This transmission of energy by the nuclei as they return to their initial state is what is observed as the MRI signal. The subtle differing characteristic of that signal from different tissues combined with complex mathematical formulas analyzed on modern computers is what enables MRI imaging to distinguish between various organs. Any imaging plane, or slice, can be projected, and then stored or printed.
The measured signal intensity depends jointly on the spin density and the relaxation times (T1 time and T2 time), with their relative importance depending on the particular imaging technique and choice of interpulse times. Any motion such as blood flow, respiration, etc. also affects the image brightness.
Magnetic resonance imaging is particularly sensitive in assessing anatomical structures, organs and soft tissues for the detection and diagnosis of a broad range of pathological conditions. MRI pictures can provide contrast between benign and pathological tissues and may be used to stage cancers as well as to evaluate the response to treatment of malignancies. The need for biopsy or exploratory surgery can be eliminated in some cases, and can result in earlier diagnosis of many diseases.

See also MRI History and Functional Magnetic Resonance Imaging (fMRI).

(MTC) This MRI method increases the contrast by removing a portion of the total signal in tissue. An off resonance radio frequency (RF) pulse saturates macromolecular protons to make them invisible (caused by their ultra-short T2* relaxation times). The MRI signal from semi-solid tissue like brain parenchyma is reduced, and the signal from a more fluid component like blood is retained.
E.g., saturation of broad spectral lines may produce decreases in intensity of lines not directly saturated, through exchange of magnetization between the corresponding states; more closely coupled states will show a greater resulting intensity change. Magnetization transfer techniques make demyelinated brain or spine lesions (as seen e.g. in multiple sclerosis) better visible on T2 weighted images as well as on gadolinium contrast enhanced T1 weighted images.
Off resonance makes use of a selection gradient during an off resonance MTC pulse. The gradient has a negative offset frequency on the arterial side of the imaging volume (caudally more off resonant and cranially less off resonant). The net effect of this type of pulse is that the arterial blood outside the imaging volume will retain more of its longitudinal magnetization, with more vascular signal when it enters the imaging volume. Off resonance MTC saturates the venous blood, leaving the arterial blood untouched.
On resonance has no effect on the free water pool but will saturate the bound water pool and is the difference in T2 between the pools. Special binomial pulses are transmitted causing the magnetization of the free protons to remain unchanged. The z-magnetization returns to its original value. The spins of the bound pool with a short T2 experience decay, resulting in a destroyed magnetization after the on resonance pulse.

See also Magnetization Transfer.

Quick Overview

Ferromagnetic metal will cause a magnetic field inhomogeneity, which in turn causes a local signal void, often accompanied by an area of high signal intensity, as well as a distortion of the image. They create their own magnetic field and dramatically alter precession frequencies of protons in the adjacent tissues. Tissues adjacent to ferromagnetic components become influenced by the induced magnetic field of the metal hardware rather than the parent field and, therefore, either fail to precess or do so at a different frequency and hence do not generate useful signal. Two components contribute to susceptibility artifact, induced magnetism in the ferromagnetic component itself and induced magnetism in protons adjacent to the component.
Artifacts from metal may have varied appearances on MRI scans due to different type of metal or configuration of the piece of metal. The biocompatibility of metallic alloys, stainless steel, cobalt chrome and titanium alloy is based on the presence of a constituent element within the alloy that has the ability to form an adherent oxide coating that is stable, chemically inert and hence biocompatible. In relation to imaging titanium alloys are less ferromagnetic than both cobalt and stainless steel, induce less susceptibility artifact and result in less marked image degradation.

Remove the metal when possible or take a not so sensitive sequence (a SE or another sequence with a rephasing 180° pulse).

See also Susceptibility Artifact.