Liver imaging can be performed with sonography, computed tomography (CT) and magnetic resonance imaging (MRI). Ultrasound is, caused by the easy access, still the first-line imaging method of choice; CT and MRI are applied whenever ultrasound imaging yields vague results. Indications are the characterization of metastases and primary liver tumors e.g., benign lesions such as focal nodular hyperplasia (FNH), adenoma, hemangioma and malignant lesions (cancer) such as hepatocellular carcinomas (HCC). The decision, which medical imaging modality is more suitable, MRI or CT, is dependent on the different factors. CT is less costly and more widely available; modern multislice scanners provide high spatial resolution and short scan times but has the disadvantage of radiation exposure.
With the introduction of high performance MR systems and advanced sequences the image quality of MRI for the liver has gained substantially. Fast spin echo or single shot techniques, often combined with fat suppression, are the most common T2 weighted sequences used in liver MRI procedures. Spoiled gradient echo sequences are used as ideal T1 weighted sequences for evaluating of the liver. The repetition time (TR) can be sufficiently long to acquire enough sections covering the entire liver in one pass, and to provide good signal to noise. The TE should be the shortest in phase echo time (TE), which provides strong T1 weighting, minimizes magnetic susceptibility effects, and permits acquisition within one breath hold to cover the whole liver. A flip angle of 80° provides good T1 weighting and less of power deposition and tissue saturation than a larger flip angle that would provide comparable T1 weighting.
Liver MRI is very dependent on the administration of contrast agents, especially when detection and characterization of focal lesions are the issues. Liver MRI combined with MRCP is useful to evaluate patients with hepatic and biliary disease.
Gadolinium chelates are typical non-specific extracellular agents diffusing rapidly to the extravascular space of tissues being cleared by glomerular filtration at the kidney. These characteristics are somewhat problematic when a large organ with a huge interstitial space like the liver is imaged. These agents provide a small temporal imaging window (seconds), after which they begin to diffuse to the interstitial space not only of healthy liver cells but also of lesions, reducing the contrast gradient necessary for easy lesion detection. Dynamic MRI with multiple phases after i.v. contrast media (Gd chelates), with arterial, portal and late phase images (similar to CT) provides additional information.
An additional advantage of MRI is the availability of liver-specific contrast agents (see also Hepatobiliary Contrast Agents). Gd-EOB-DTPA (gadoxetate disodium, Gadolinium ethoxybenzyl dimeglumine, EOVIST Injection, brand name in other countries is Primovist) is a gadolinium-based MRI contrast agent approved by the FDA for the detection and characterization of known or suspected focal liver lesions.
Gd-EOB-DTPA provides dynamic phases after intravenous injection, similarly to non-specific gadolinium chelates, and distributes into the hepatocytes and bile ducts during the hepatobiliary phase. It has up to 50% hepatobiliary excretion in the normal liver.
Since ferumoxides are not eliminated by the kidney, they possess long plasmatic half-lives, allowing circulation for several minutes in the vascular space. The uptake process is dependent on the total size of the particle being quicker for larger particles with a size of the range of 150 nm (called superparamagnetic iron oxide). The smaller ones, possessing a total particle size in the order of 30 nm, are called ultrasmall superparamagnetic iron oxide particles and they suffer a slower uptake by RES cells. Intracellular contrast agents used in liver MRI are primarily targeted to the normal liver parenchyma and not to pathological cells. Currently, iron oxide based MRI contrast agents are not marketed.
Beyond contrast enhanced MRI, the detection of fatty liver disease and iron overload has clinical significance due to the potential for evolution into cirrhosis and hepatocellular carcinoma. Imaging-based liver fat quantification (see also Dixon) provides noninvasively information about fat metabolism; chemical shift imaging or T2*-weighted imaging allow the quantification of hepatic iron concentration.

See also Abdominal Imaging, Primovistâ„¢, Liver Acquisition with Volume Acquisition (LAVA), T1W High Resolution Isotropic Volume Examination (THRIVE) and Bolus Injection.

For Ultrasound Imaging (USI) see Liver Sonography at Medical-Ultrasound-Imaging.com.

Advantages of low field imaging are the small-sized 5 Gauss fringe field and therefore the less static magnetic field exposure for the surrounding area, as well as less contraindications causing lower risks for the MRI safety by implemented metal and magnetic devices and equipment.
Low field systems are sometimes for restricted use, e.g. dedicated extremity scanner or open MRI devices. Open MRI devices equipped with permanent magnets are well-suited for MR guided interventions because these machines combine the lower magnetic fields of this type of magnets and the better patient access of open MRI scanner.
In some cases, the contrast of different tissues is better at lower field strength, depending on their T1 or T2 relaxation times. The disadvantage of the lower signal to noise ratio are a poor resolution and a longer scan time for a good image quality.

See also Claustrophobia, Contraindications and MRI Safety.

See also the related poll result: 'In 2010 your scanner will probably work with a field strength of'

From Siemens Medical Systems;
Received FDA clearance in 2007.
The MAGNETOM Verio provides up to 102 integrated matrix coil elements and up to 32 independent radiofrequency channels that allow flexible coil combinations to make patient and coil repositioning virtually unnecessary. The Tim (total imaging matrix) technology also increases patient throughput due to a shorter scan time.
The open bore design offers great comfort for patients of all shapes and sizes.

Open MRI scanners have been developed for people who are anxious or obese or for examination of small parts of the body, such as the extremities (knee, shoulder). In addition, some systems offer imaging in different positions and sequences of movements. The basic technology of an open MRI machine is similar to that of a traditional MRI device. The major difference for the patient is that instead of lying in a narrow tunnel, the imaging table has more space around the body so that the magnet does not completely surround the person being tested.
Types of constructions:
Difficulties with a traditional MRI scan include claustrophobia and patient size or, for health related reasons, patients who are not able to receive this type of diagnostic test. The MRI unit is a limited space, and some patients may be too large to fit in a narrow tunnel. In addition, weight limits can restrict the use of some scanners. The open MRI magnet has become the best option for those patients.
All of the highest resolution MRI scanners are tunnels and tend to accentuate the claustrophobic reaction. While patients may find the open MRI scanners easier to tolerate, some machines use a lower field magnet and generates lower image quality or have longer scan time. The better performance of an advanced open MRI scanner allows good image quality caused by the higher signal to noise ratio with maximum patient comfort.

See also Claustrophobia, MRI scan and Knee MRI.

The data acquisition beyond the FOV in phase encoding direction, with doubling the number of acquisitions and the scan time.

See also Oversampling and Aliasing Artifact.