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Magnetic Field Gradient
 
Magnetic field gradients are used to change the strength of the magnetic field Bo in a certain direction. Gradients are used in MR imaging with selective excitation to select a region for imaging and also to be able to encode the location of MR signals received from the object being imaged. The field strength is measured in Tesla per meter (T/m).
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(MRS / MRSI - Magnetic Resonance Spectroscopic Imaging) A method using the NMR phenomenon to identify the chemical state of various elements without destroying the sample. MRS therefore provides information about the chemical composition of the tissues and the changes in chemical composition, which may occur with disease processes.
Although MRS is primarily employed as a research tool and has yet to achieve widespread acceptance in routine clinical practice, there is a growing realization that a noninvasive technique, which monitors disease biochemistry can provide important new information for the clinician.
The underlying principle of MRS is that atomic nuclei are surrounded by a cloud of electrons, which very slightly shield the nucleus from any external magnetic field. As the structure of the electron cloud is specific to an individual molecule or compound, then the magnitude of this screening effect is also a characteristic of the chemical environment of individual nuclei.
In view of the fact that the resonant frequency is proportional to the magnetic field that it experiences, it follows that the resonant frequency will be determined not only by the external applied field, but also by the small field shift generated by the electron cloud. This shift in frequency is called the chemical shift (see also Chemical Shift). It should be noted that chemical shift is a very small effect, usually expressed in ppm of the main frequency. In order to resolve the different chemical species, it is therefore necessary to achieve very high levels of homogeneity of the main magnetic field B0. Spectra from humans usually require shimming the magnet to approximately one part in 100. High resolution spectra of liquid samples demand a homogeneity of about one part in 1000.
In addition to the effects of factors such as relaxation times that can affect the NMR signal, as seen in magnetic resonance imaging, effects such as J-modulation or the transfer of magnetization after selective excitation of particular spectral lines can affect the relative strengths of spectral lines.
In the context of human MRS, two nuclei are of particular interest - H-1 and P-31. (PMRS - Proton Magnetic Resonance Spectroscopy) PMRS is mainly employed in studies of the brain where prominent peaks arise from NAA, choline containing compounds, creatine and creatine phosphate, myo-inositol and, if present, lactate; phosphorus 31 MR spectroscopy detects compounds involved in energy metabolism (creatine phosphate, adenosine triphosphate and inorganic phosphate) and certain compounds related to membrane synthesis and degradation. The frequencies of certain lines may also be affected by factors such as the local pH. It is also possible to determine intracellular pH because the inorganic phosphate peak position is pH sensitive.
If the field is uniform over the volume of the sample, "similar" nuclei will contribute a particular frequency component to the detected response signal irrespective of their individual positions in the sample. Since nuclei of different elements resonate at different frequencies, each element in the sample contributes a different frequency component. A chemical analysis can then be conducted by analyzing the MR response signal into its frequency components.

See also Spectroscopy.
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Accuracy of Proton Magnetic Resonance Spectroscopy in Distinguishing Neoplastic From Non-neoplastic Brain Lesions
Saturday, 2 December 2023   by www.cureus.com    
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Multiple Line Scan Imaging
 
(MLSI) Variations of sequential line imaging techniques that can be used if selective excitation methods that do not affect adjacent lines are employed. Adjacent lines are imaged while waiting for relaxation of the first line toward equilibrium, which may result in decreased image acquisition time. A different type of MLSI uses simultaneous excitation of two or more lines with different phase encoding followed by suitable decoding.
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Multiple Slice ImagingInfoSheet: - Sequences - 
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A usual variation of sequential plane imaging technique that can be used with selective excitation technique that does not affect adjacent slices. Since, in SE imaging TR longer than TE, the machine would be idling most of the time, if a single slice would be acquired; multiple slice imaging was introduced early on. Adjacent slices are imaged while waiting for relaxation of the first slice toward equilibrium, resulting in decreased image acquisition time for the set of slices. The maximum number of slices of a pulse sequence depends on the repetition time.
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Saturation Pulses
 
Sequence of RF (and gradient) pulses designed to produce saturation, typically in a selected region or set of regions, most often by the use of selective excitation followed by a spoiler pulse. Similar to some spectral suppression techniques. Can be used to reduce signal from flowing blood by saturating regions upstream from region being imaged.
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