Process by which regions of tissue are selectively sampled to produce spectra from defined volumes in space. These methods may be employed to sample a single region in space (single voxel method) or multiple regions simultaneously (multivoxel methods). The spatial selectivity can be achieved by a variety of methods including surface coils, surface coils in conjunction with RF gradient methods, or RF pulses in combination with switched magnetic field gradients, for example, volume-selective excitation. An indirect method of achieving spatial selectivity is the destruction of coherence of the magnetization in regions that lie outside the region of interest. A variety of spatial encoding schemes have been employed for multivoxel localization. See Chemical shift imaging.