Edward Purcell and Felix Bloch discovered the basic of spectroscopy in 1946 (see MRI History). Nuclear magnetic resonance spectroscopy (NMR Spectroscopy or MRS) is an analytical tool, based on nuclei that have a spin (nuclei with an odd number of neutrons and/or protons) like 1H, 13C, 17O, 19F, 31P etc.
Through nuclear magnetic principles as precession, chemical shift, spin spin coupling etc., the analysis of the content, purity, and molecular structure of a sample is possible. The spectrum produced by this process contains a number of peaks; the highs and the positions of these peaks allow the exact analysis. Unknown compounds can be matched against spectral libraries. Even very complex organic compounds as enzymes and proteins can be determined. For the wide uses of NMR spectroscopy (from mineralogy to medicine) there is a variety of different techniques available.
See Spectroscopic Imaging Techniques.

The combination of single volume spectroscopy and chemical shift imaging. The chemical shift measurement is performed over a selectively-excited volume of interest. Areas with strong distorting signal are not stimulated and therefore do not append signal to the spectra.

See also Hybrid Imaging.

(EPS) See Spectroscopy.

(GES) See Gradient Echo Sequence and Spectroscopy.

(SVS) This method maps the metabolic information from the VOI in a spectrum. Single volume techniques are advantageous in case of pathological changes that cannot spatially be limited to a few VOI; by using local volume sensitive shim the local magnetic field inhomogeneity can be compensated.