(CSI) Chemical shift imaging is an extension of MR spectroscopy, allowing metabolite information to be measured in an extended region and to add the chemical analysis of body tissues to the potential clinical utility of Magnetic Resonance. The spatial location is phase encoded and a spectrum is recorded at each phase encoding step to allow the spectra acquisition in a number of volumes covering the whole sample. CSI provides mapping of chemical shifts, analog to individual spectral lines or groups of lines.
Spatial resolution can be in one, two or three dimensions, but with long acquisition times od full 3D CSI. Commonly a slice-selected 2D acquisition is used. The chemical composition of each voxel is represented by spectra, or as an image in which the signal intensity depends on the concentration of an individual metabolite. Alternatively frequency-selective pulses excite only a single spectral component.
There are several methods of performing chemical shift imaging, e.g. the inversion recovery method, chemical shift selective imaging sequence, chemical shift insensitive slice selective RF pulse, the saturation method, spatial and chemical shift encoded excitation and quantitative chemical shift imaging.

See also Magnetic Resonance Spectroscopy.

The range of signal intensities that may need to be distinguished in an image or spectrum or that can be distinguished by the electronic components. If the signal dynamic range is too great, the need to keep the highest intensities from overloading the digitizer may result in the weaker features being lost in the digitization noise. This can be dealt with by using an analog to digital converter with a larger range of sensitivity or by using techniques to reduce the dynamic range, e.g. suppressing the signal from water in order to detect the signal from less abundant compounds.

(ESR) Electron spin resonance is a spectroscopic technique to identify paramagnetic substances. This magnetic resonance phenomenon investigates the nature of the bonding within molecules by identifying unpaired electrons, e.g. in free radicals and their interaction with their immediate surroundings. The Larmor frequency are much higher than corresponding NMR frequencies in the same static magnetic field.
Nuclei with an odd number of neutrons and/or protons, because of their spin, react like tiny magnets and can be lined up in an applied magnetic field. Energy applied by alternating radio frequency radiation is absorbed when its frequency coincides with that of precession of the electron magnets. The spectrum of radiation absorbed as the field changes gives information valuable in chemistry, biology, and medicine since over 50 years.

A feedback control used to maintain the static magnetic field at a constant strength, usually by monitoring the resonance frequency of a reference sample or line in the spectrum.

(FT) The Fourier transformation is a mathematical procedure to separate out the frequency components of a signal from its amplitudes as a function of time, or the inverse Fourier transformation (IFT) calculates the time domain from the frequency domain. The FT is used to generate the spectrum from the free induction decay or spin echo in the pulse MR technique and is essential to most MR imaging techniques. The Fourier transformation can be generalized to multiple dimensions, e.g. to relate an image to its corresponding k-space representation, or to include chemical shift information in some chemical shift imaging techniques. Fourier transformation analysis allows spatial information to be reconstructed from the raw data.