The element helium (He) was discovered 1868 when P.J.C. Janssen and N. Lockyer detected a new line in the solar spectrum during the solar eclipse. Lockyer and E. Frankland suggested the name helium (Gr. Helios, the sun) for the new element. In 1895, helium was discovered in the uranium mineral cleveite and in 1907 it was found out that alpha particles are helium nuclei.
Properties: Helium belongs to the noble gases, is colorless, odorless, and occurs in two naturally isotopes, helium 3 and helium 4. As an inert gas, helium does not react chemically largely and don't burns. Helium 4 makes up over 99% of naturally occurring helium atoms. Helium is extracted from natural gas e.g. present in various radioactive minerals as a decay product. Deposits and sources are in the USA, Poland, the USSR, and a few in India. The rare deposits and increased consumption lead to a shortage of this gas.
K. Onnes worked for many years to liquefy helium, which persisted as a gas to the lowest temperature. Helium does not freeze at atmospheric pressure. The density of helium vapor at his boiling point of 4.2 Kelvin is very high, with the vapor expanding greatly when heated to room temperature. Nb, Tc, Pb, La, V, and Ta are superconductors at liquid helium temperature. Liquid helium is commonly used as a cryogen for superconducting magnets. A rapid evaporation of the cryogen is named Quench. See also Quenching.

Cryogenic liquids and their associated cold vapors can produce effects on the skin similar to a thermal burn and can cause frostbite. Prolonged breathing of extremely cold gases may damage the lungs and in absence of enough air or oxygen, asphyxiation and death can occur. Unprotected skin can stick to very cold metal (e.g. cooled by liquid helium) and then tear when pulled away.

(ISIS) Image selected in vivo spectroscopy is used as a localization sequence to provide complete gradient controlled three-dimensional localization with a reduced number of sequence cycles, e.g. for in vivo 31P spectroscopy. The ISIS method generates three 180° pulses prior to a 90° pulse, after which the free induction decay is recorded. Specific 180° pulses (slice-selective) are combined and the FID's added or subtracted to generate a spectrum.
An advantage of the ISIS method is that the magnetization (before the final 90° pulse) is predominantly along the z-axis and so T2 effects are relatively small. This explains the value of this technique for 31P data acquisition, because some phosphorus metabolites (e.g. ATP) have short T2 values.
A disadvantage is that eight acquisitions are required to accomplish the spatial localization, therefore the sequence cannot be used for localized shimming. Another problem, because any variation between these data collections (for example, due to movement) will degrade these applications, can be solved by incorporating outer volume suppression techniques such as OSIRIS (modified ISIS).

Spread in frequency of a resonance line in a MR spectrum. A common measure of the line width is full width at half maximum (FWHM).

Means of selecting a restricted region from which the signal is received. These can include the use of surface coils, with or without magnetic field gradients. Generally used to produce a spectrum from the desired region.

Usual shape of the lines in a NMR spectrum, characterized by a central peak with long tails; proportional to 1/[(1/T2)2 + (f - fo)2], where f is frequency and fo is the frequency of the peak (i.e., central resonance frequency). A Lorentzian function is the Fourier transformation of a decaying exponential.