(IRSE) Form of inversion recovery imaging in which the signal is detected as a spin echo. For TE short compared to the T2relaxation time, there will be only a small effect of T2 differences on image intensities; for longer TE's, the effect of T2 may be significant.
Lung imaging is furthermore a challenge in MRI because of the predominance of air within the lungs and associated susceptibility issues as well as low signal to noise of the inflated lung parenchyma. Cardiac and respiratory triggered or breath hold sequences allow diagnostic imaging, however a comparable image quality with computed tomography is still difficult to achieve.
Assumptions for lung MRI:
Very short transverse relaxation times and significant diffusion yielding short T2 (30-70 msec), short T2* (1-3 msec), and additional long T1 relaxation times (1300-1500 msec).
•
The extreme short T2 values are responsible for a fast signal decay during a single shot readout, resulting in blurring.
MR myelography is studying the spinal canal and subarachnoid space by high-resolution MRI with a technique in which a sequence with strong T2 weighting is used to provide high contrast between the "dark" spinal cord and its nerves and the surrounding "bright" cerebrospinal fluid. MR myelography as part of an entire MR examination has virtually replaced X-ray myelography.
Used sequences are T2 weightedfast spin echo pulse sequences or a refocused gradient echopulse sequence with strong T2 weighting.
(MT) Magnetization Transfer was accidentally discovered by Wolff and Balaban in 1989. Conventional MRI is based on the differences in T1, T2 and the proton density (water content and the mobility of water molecules) in tissue; it relies primarily on free (bulk) water protons. The T2 relaxation times are greater than 10 ms and detectable. The T2 relaxation times of protons associated with macromolecules are less then 1 ms and not detectable in MRI.
Magnetization Transfer Imaging (MTI) is based on the magnetization interaction (through dipolar and/or chemical exchange) between bulk water protons and macromolecular protons. By applying an off resonanceradio frequency pulse to the macromolecular protons, the saturation of these protons is then transferred to the bulk water protons. The result is a decrease in signal (the net magnetization of visible protons is reduced), depending on the magnitude of MT between tissue macromolecules and bulk water. With MTI, the presence or absence of macromolecules (e.g. in membranes, brain tissue) can be seen.
The magnetization transfer ratio (MTR) is the difference in signal intensity with or without MT.
Multi echo imaging sequences use a series of echoes acquired as a train following after a single excitation pulse. Multiple symmetrical or asymmetrical echoes can be acquired, typically T2 weighted. In spin echo imaging, each echo is formed by a 180° pulse, but also a FSE (TSE, RARE) or EPI sequence can be used.
As a difference to a normal fast spin echo sequence, in multi echo imaging, separate images are produced from each echo of the train with different T2 weightings. The signal height reduces with transverse relaxation. This drop in signal can be used to calculate a pure T2 image.