T2* (also called T2 Star) is composed of molecular interactions (spin spin relaxation) and local magnetic field non-uniformities. Caused by this the protons precess at slightly different frequencies. The T2* effect cause a rapid loss in coherence and transverse magnetization. The T2* time is less than the T2 time.

See also T2* Time, T2 Star.

(T2* or T two star) The observed time constant of the FID due to loss of phase coherence among spins oriented at an angle to the static magnetic field. Commonly due to a combination of magnetic field inhomogeneities, dB, and spin spin transverse relaxation, with the result of rapid loss in transverse magnetization and MRI signal. MRI signals can usually still be recovered as a spin echo in times less than or on the order of T2.
1/T2 * @ 1/T2 + Dw/2; Dw = gDB. The FID will generally not be exponential, so that T2* will not be unique.

The T2 relaxation time (spin spin relaxation time or transverse relaxation time), is a biological parameter that is used in MRIs to distinguish between tissue types and is termed 'Time 2' or T2. It is a tissue-specific time constant for protons and is dependent on the exchanging of energy with near by nuclei. T2 weighted images rely upon local dephasing of spins following the application of the transverse energy pulse. T2 is the decay of magnetization perpendicular to the main magnetic field (in an ideal homogeneous field).
Due to interaction between the spins, they lose their phase coherence, which results in a loss of transverse magnetization and MRI signal. After time T2 transverse magnetization has lost 63% of its original value. This tissue parameter determines the contrast.
The T2 relaxation is temperature dependent. At a lower temperature molecular motion is reduced and the decay times are reduced.
Fat has a very efficient energy exchange and therefore it has a relatively short T2.
Water is less efficient than fat in the exchange of energy, and therefore it has a long T2 time.

See also T2 Weighted Image and Magnetic Resonance Imaging MRI.

(T2 Star) The characteristic time constant that describes the decay of transverse magnetization, taking into account the inhomogeneity in static magnetic fields and the spin spin relaxation in the human body. This results in a rapid loss of phase coherence and the MRI signal. The T2* time is always less than the T2 time.

Often used to indicate an image where most of the contrast between tissues or tissue states is due to differences in tissue T2 created typically by using longer TE and TR times.
This term may be misleading in that the potentially important effects of tissue density differences and the range of tissue T2 values are often ignored.
Choosing the machine parameters such that TR greater than T1 (typically greater than 2 000 ms) and TE less than T2 (typically greater than 100 ms) and noting that (1-exp(-TR/T1) = 1 for TR/T1 much greater than 1, will reduce Eq. 1 to the expression
Mxy = Mxy0exp(-TE/T2)
which is dependent on T2 only, hence the term T2 weighting. Therefore T2 weighted image contrast state is approached by imaging with a TR long compared to tissue T1 (to reduce T1 contribution to image contrast) and a TE between the longest and shortest tissue T2s of interest. A TR greater than 3 times the longest T1 is required for the T1 effect to be less than 5%. Due to the wide range of T1 and T2 and tissue density values that can be found in the body, an image that is T2 weighted for some tissues may not be so for others.
See also T2 Time.
Lesions with short T2 are (dark in T2 weighted sequences):
acute haemorrhage (deoxyHb)
haemosiderin
physiologic iron (basal ganglia, etc.)
mucinous lesions.