Rapid echo planar imaging and high-performance MRIgradient systems create fast-switching magnetic fields that can stimulate muscle and nerve tissues produced by either changing the electrical resistance or the potential of the excitation. There are apparently no effects on the conduction of impulses in the nerve fiber up to field strength of 0.1 T. A preliminary study has indicated neurological effects by exposition to a whole body imager at 4.0 T. Theoretical examinations argue that field strengths of 24 T are required to produce a 10% reduction of nerve impulse conduction velocity.
Nerve stimulations during MRI scans can be induced by very rapid changes of the magnetic field. This stimulation may occur for example during diffusion weighted sequences or diffusion tensor imaging and can result in muscle contractions caused by effecting motor nerves. The so-called magnetic phosphenes are attributed to magnetic field variations and may occur in a threshold field change of between 2 and 5 T/s. Phosphenes are stimulations of the optic nerve or the retina, producing a flashing light sensation in the eyes. They seem not to cause any damage in the eye or the nerve.
Varying magnetic fields are also used to stimulate bone-healing in non-unions and pseudarthroses. The reasons why pulsed magnetic fields support bone-healing are not completely understood. The mean threshold levels for various stimulations are 3600 T/s for the heart, 900 T/s for the respiratory system, and 60 T/s for the peripheral nerves.
Guidelines in the United States limit switching rates at a factor of three below the mean threshold for peripheral nerve stimulation. In the event that changes in nerve conductivity happens, the MRI scan parameters should be adjusted to reduce dB/dt for nerve stimulation.
• For this and other aspects of MRI safety see our InfoSheet about MRI Safety.
(TOF) The time of flight angiography is used for the imaging of vessels. Usually the sequence type is a gradient echosequences with short TR, acquired with slices perpendicular to the direction of blood flow.
The source of diverse flow effects is the difference between the unsaturated and presaturated spins and creates a bright vascular image without the invasive use of contrast media. Flowing blood moves unsaturated spins from outside the slice into the imaging plane. These completely relaxed spins have full equilibriummagnetization and produce (when entering the imaging plane) a much higher signal than stationary spins if a gradient echo sequence is generated. This flow related enhancement is also referred to as entry slice phenomenon, or inflow enhancement.
Performing a presaturationslab on one side parallel to the slice can selectively destroy the MR signal from the in-flowing blood from this side of the slice. This allows the technique to be flow direction sensitive and to separate arteriograms or venograms. When the local magnetization of moving blood is selectively altered in a region, e.g. by selective excitation, it carries the altered magnetization with it when it moves, thus tagging the selected region for times on the order of the relaxation times.
For maximum flow signal, a complete new part of blood has to enter the slice every repetition (TR) period, which makes time of flight angiography sensitive to flow-velocity. The choice of TR and slice thickness should be appropriate to the expected flow-velocities because even small changes in slice thickness influences the performance of the TOF sequence.
The use of sequential 2 dimensional Fourier transformation (2DFT) slices, 3DFT slabs, or multiple 3D slabs (chunks) are depending on the coverage required and the range of flow-velocities.
3D TOF MRA is routinely used for evaluating the Circle of Willis.
Postprocessing techniques for artery vein separation by segmentation of the entire vessel structures from the background with different approaches.
Phase contrast imaging can also be used to differentiate arteries and
veins based on flow-velocity or flow direction.
The fact that arterial and venous flows are in opposite directions also has the advantage to separate the vessels in time of flight angiography.