(MSI) The combination of biomagnetic field detection and MR imaging into a merged data set. Most applications of MSI involve the combined use of MRI and measurement of magnetic fields created by electric currents in the brain, so-called magnetoencephalography MEG.
MEG allows calculation of the source of the measured biomagnetic fields, and thereby localization of many regional brain functions, such as mapping of the sensorimotor, auditory and visual cortex and also localization of epileptogenic foci. The MEG coordinate system is defined by anatomical landmarks, which are easily identified also with MRI, making it possible to align the 3D MEG data with the 3D MR image data. The resulting magnetic source images show the spatial relationships between the functional area provided by MEG and the neighboring anatomy and pathology, both provided by MRI.
Cardiac applications of MSI are also being explored. The electric currents in the myocardium create extrathoracic magnetic fields and the source of these fields may be calculated by the same principles as those used in MEG. Possible cardiac applications include mapping of arrhythmogenic sites prior to ablation therapy.

The definition of imaging is the visual representation of an object. Medical imaging began after the discovery of x-rays by Konrad Roentgen 1896. The first fifty years of radiological imaging, pictures have been created by focusing x-rays on the examined body part and direct depiction onto a single piece of film inside a special cassette. The next development involved the use of fluorescent screens and special glasses to see x-ray images in real time.
A major development was the application of contrast agents for a better image contrast and organ visualization. In the 1950s, first nuclear medicine studies showed the up-take of very low-level radioactive chemicals in organs, using special gamma cameras. This medical imaging technology allows information of biologic processes in vivo. Today, PET and SPECT play an important role in both clinical research and diagnosis of biochemical and physiologic processes. In 1955, the first x-ray image intensifier allowed the pick up and display of x-ray movies.
In the 1960s, the principals of sonar were applied to diagnostic imaging. Ultrasonic waves generated by a quartz crystal are reflected at the interfaces between different tissues, received by the ultrasound machine, and turned into pictures with the use of computers and reconstruction software. Ultrasound imaging is an important diagnostic tool, and there are great opportunities for its further development. Looking into the future, the grand challenges include targeted contrast agents, real-time 3D ultrasound imaging, and molecular imaging.
Digital imaging techniques were implemented in the 1970s into conventional fluoroscopic image intensifier and by Godfrey Hounsfield with the first computed tomography. Digital images are electronic snapshots sampled and mapped as a grid of dots or pixels. The introduction of x-ray CT revolutionised medical imaging with cross sectional images of the human body and high contrast between different types of soft tissue. These developments were made possible by analog to digital converters and computers. The multislice spiral CT technology has expands the clinical applications dramatically.
The first MRI devices were tested on clinical patients in 1980. The spread of CT machines is the spur to the rapid development of MRI imaging and the introduction of tomographic imaging techniques into diagnostic nuclear medicine. With technological improvements including higher field strength, more open MRI magnets, faster gradient systems, and novel data-acquisition techniques, MRI is a real-time interactive imaging modality that provides both detailed structural and functional information of the body.
Today, imaging in medicine has advanced to a stage that was inconceivable 100 years ago, with growing medical imaging modalities:
All this type of scans are an integral part of modern healthcare. Because of the rapid development of digital imaging modalities, the increasing need for an efficient management leads to the widening of radiology information systems (RIS) and archival of images in digital form in picture archiving and communication systems (PACS). In telemedicine, healthcare professionals are linked over a computer network. Using cutting-edge computing and communications technologies, in videoconferences, where audio and visual images are transmitted in real time, medical images of MRI scans, x-ray examinations, CT scans and other pictures are shareable.
See also Hybrid Imaging.

See also the related poll results: 'In 2010 your scanner will probably work with a field strength of', 'MRI will have replaced 50% of x-ray exams by'

Porphyrins occur naturally in plants and animals. All porphyrin molecules feature an aromatic macrocycle ring with a central binding site. This site accommodates transition metals, which are held in place by inward-facing nitrogen atoms. Metalloporphyrins have usually a low toxicity and a potential of a selective uptake in tumors or necrosis. These properties are advantageous for a use as MRI tumor specific agents with positive enhancement. These contrast agents enhance tumors on T1 weighted sequences, which are isointense to surrounding tissues. Porphyrin-based compounds have also necrosis avid properties; they can depict the extent of myocardial infarction as defined by histopathology.
Metalloporphyrins are also used in photodynamic therapy of tumors. The compounds contain a 'lone star' metal atom at the center of the ring and are 'bigger than the average porphyrin'. They contain five N atoms in the central chelating core and this allows them to form complexes with large trivalent lanthanide metals, which have useful cancer therapy properties.

See also Classifications, Characteristics, etc., Gadophrin, MnIIITPPS4, Necrosis Avid Contrast Agent.

Many MR imaging techniques using Motion Probing Gradients (MPG's) such as Spin Echo (SE), Stimulated Echo (STE), Rapid Acquisition with Relaxation Enhancement (RARE), Turbo-SE, and SE-EPI (Echo Planar Imaging for Spin echo acquisition), Spiral imaging, and Projection reconstruction including PROPELLER are applicable to DWI. In diffusion weighted imaging, 2 MPG's are required. The MPG's are put symmetrically into both sides of a 180° or 90° RF pulse to change the direction of the magnetized spin in the X-Y plane for spin echo or stimulated echo acquisition.

Multi echo imaging sequences use a series of echoes acquired as a train following after a single excitation pulse. Multiple symmetrical or asymmetrical echoes can be acquired, typically T2 weighted. In spin echo imaging, each echo is formed by a 180° pulse, but also a FSE (TSE, RARE) or EPI sequence can be used. As a difference to a normal fast spin echo sequence, in multi echo imaging, separate images are produced from each echo of the train with different T2 weightings. The signal height reduces with transverse relaxation. This drop in signal can be used to calculate a pure T2 image.

See also Fast Spin Echo.